ACTL8 and CERT1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		ACTL8	CERT1
Description		actin like 8	ceramide transporter 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Actin Filament Actin Cytoskeleton Membrane Axon NuA4 Histone Acetyltransferase Complex Synapse	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Protein Kinase Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton	Protein Binding Lipid Binding Kinase Activity Identical Protein Binding Phosphatidylinositol-4-phosphate Binding Ceramide Binding Ceramide Transfer Activity Ceramide 1-phosphate Binding Ceramide 1-phosphate Transfer Activity
	Biological Process	Axonogenesis Epithelial Cell Differentiation Cell Motility Postsynaptic Actin Cytoskeleton Organization	Cell Morphogenesis In Utero Embryonic Development Heart Morphogenesis Ceramide Metabolic Process Lipid Transport Muscle Contraction Immune Response Mitochondrion Organization Endoplasmic Reticulum Organization Signal Transduction Cell Population Proliferation Response To Endoplasmic Reticulum Stress ER To Golgi Ceramide Transport Ceramide Transport Lipid Homeostasis Intermembrane Lipid Transfer Intermembrane Sphingolipid Transfer Ceramide 1-phosphate Transport
Pathways
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 31219225) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		2 interacting genes: CERT1 UBC	18 interacting genes: ACTL8 AQP2 ARL6IP1 BSND CBS COL4A3 CSNK1G2 FTSJ1 ITGB3BP MINAR1 PM20D2 POM121 REEP6 RTN3 RTN4 SMU1 STX2 TGM2
Entrez ID		81569	10087
HPRD ID		11274	05246
Ensembl ID		ENSG00000117148	ENSG00000113163
Uniprot IDs		Q9H568	A0A2R8Y7C5 Q9Y5P4
PDB IDs			2E3M 2E3N 2E3O 2E3P 2E3Q 2E3R 2E3S 2RSG 2Z9Y 2Z9Z 3H3Q 3H3R 3H3S 3H3T 4HHV 5JJD 5ZYG 5ZYH 5ZYI 5ZYJ 5ZYK 5ZYL 5ZYM 6IEZ 6IF0 6J0O 6J81
Enriched GO Terms of Interacting Partners?		Ceramide 1-phosphate Transfer Activity ER To Golgi Ceramide Transport Ceramide 1-phosphate Binding Ceramide 1-phosphate Transport Ceramide Transfer Activity Intermembrane Sphingolipid Transfer Ceramide Binding Protein Tag Activity Ceramide Transport Endoplasmic Reticulum Membrane Intracellular Lipid Transport Intermembrane Lipid Transfer Phosphatidylinositol-4-phosphate Binding	Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization S-adenosyl-L-methionine Binding Endoplasmic Reticulum Tubular Network Regulation Of Vasculature Development Regulation Of Angiogenesis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation Endoplasmic Reticulum Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Regulation Of Amyloid-beta Formation TRNA (guanosine(34)-2'-O)-methyltransferase Activity Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Para-aminobenzoyl-glutamate Hydrolase Activity Regulation Of Amyloid Precursor Protein Catabolic Process Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity Basolateral Plasma Membrane Cysteine Biosynthetic Process From Serine Cystathionine Beta-synthase Activity Apoptotic Process Protein Deamination Wobble Position Ribose Methylation TRNA 2'-O-methyltransferase Activity Folic Acid Catabolic Process Cell Death Programmed Cell Death
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