ZPBP and ZP2

Number of citations of the paper that reports this interaction (PubMedID 10924747)
0

Data Source:
HPRD (in vitro)

		ZPBP	ZP2
Description		zona pellucida binding protein	zona pellucida glycoprotein 2
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Acrosomal Membrane Zona Pellucida Receptor Complex Extracellular Region Nucleus Membrane Cytoplasmic Vesicle	Extracellular Region Multivesicular Body Endoplasmic Reticulum Plasma Membrane Membrane Extracellular Matrix Egg Coat
	Molecular Function		Protein Binding Coreceptor Activity Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding
	Biological Process	Acrosome Assembly Binding Of Sperm To Zona Pellucida	Single Fertilization Binding Of Sperm To Zona Pellucida Regulation Of Acrosome Reaction Prevention Of Polyspermy
Pathways			Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463 28067908) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Metabolite levels ( 23823483) Total ventricular volume (Alzheimer's disease interaction) ( 21116278)	Pelvic organ prolapse ( 26545240)
Interacting Genes		3 interacting genes: CALU ERRFI1 ZP2	2 interacting genes: ACR ZPBP
Entrez ID		11055	7783
HPRD ID		18364	01689
Ensembl ID		ENSG00000042813	ENSG00000103310
Uniprot IDs		Q9BS86	Q05996
PDB IDs			8RKE 8RKF
Enriched GO Terms of Interacting Partners?		Sarcoplasmic Reticulum Lumen Structural Constituent Of Egg Coat Regulation Of Acrosome Reaction Prevention Of Polyspermy Acrosin Binding Regulation Of Fertilization Egg Coat Negative Regulation Of Protein Autophosphorylation Chondrocyte Proliferation Negative Regulation Of Collagen Biosynthetic Process Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Oviduct Epithelium Development Lung Vasculature Development Limb Joint Morphogenesis Uterine Epithelium Development Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Lung Epithelium Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Response To 1-oleoyl-sn-glycerol 3-phosphate Cellular Hyperosmotic Response Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cellular Response To Platelet-derived Growth Factor Stimulus Uterus Development Regulation Of Protein Tyrosine Kinase Activity Bile Acid Biosynthetic Process Response To Platelet-derived Growth Factor Hyperosmotic Response Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Dexamethasone Stimulus Binding Of Sperm To Zona Pellucida Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of ERBB Signaling Pathway Bile Acid Metabolic Process Response To Progesterone Regulation Of Signaling Receptor Activity Sperm-egg Recognition Regulation Of Collagen Biosynthetic Process Negative Regulation Of Interleukin-1 Production Regulation Of Keratinocyte Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Multivesicular Body Embryo Implantation	Binding Of Sperm To Zona Pellucida Sperm-egg Recognition Cell-cell Recognition Acrosomal Vesicle Cell Recognition Acrosome Matrix Dispersal Amidase Activity Acrosomal Matrix Fucose Binding Zona Pellucida Receptor Complex Penetration Of Zona Pellucida Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Acrosome Reaction Golgi-associated Vesicle Positive Regulation Of Lyase Activity Positive Regulation Of Cyclase Activity D-mannose Binding Acrosomal Membrane Acrosome Assembly Copper Ion Binding Reproductive Process Secretory Granule Organization Single Fertilization Protease Binding Serine-type Peptidase Activity Extracellular Region Fertilization Serine-type Endopeptidase Activity
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