ITIH1 and ARF4

Data Source: HiPPIP (Novel)

		ITIH1	ARF4
Name		inter-alpha-trypsin inhibitor heavy chain 1	ARF GTPase 4
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix Extracellular Exosome Blood Microparticle	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Dendritic Spine Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Peptidase Inhibitor Activity	Nucleotide Binding GTPase Activity Guanyl-nucleotide Exchange Factor Activity Epidermal Growth Factor Receptor Binding Protein Binding GTP Binding NAD+-protein-arginine ADP-ribosyltransferase Activity Phospholipase D Activator Activity
	Biological Process	Hyaluronan Metabolic Process	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Epidermal Growth Factor Receptor Signaling Pathway Learning Protein Transport Vesicle-mediated Transport Cell Migration Negative Regulation Of Apoptotic Process Apical Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Transcription By RNA Polymerase II Response To Axon Injury Regulation Of Synapse Organization Cilium Assembly Dendritic Spine Development Protein Localization To Cilium Regulation Of Postsynapse Organization Regulation Of Cilium Assembly Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		None	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Guanosine-5'-Diphosphate
GWAS		A body shape index ( 34021172 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 21926972 34002096 33263727 31043756 19416921 ) Body mass index ( 25673413 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Cortical surface area (MOSTest) ( 32665545 ) General cognitive ability ( 29844566 ) Glaucoma (primary open-angle) ( 25173105 ) Osteoarthritis (hip) ( 30374069 ) Pulse pressure ( 30578418 ) Schizophrenia ( 29483656 25056061 23974872 ) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: ARF4 ARIH2 CALR PHAX RBM15B	2 novel interactors: ITIH1 RHOA
Interacting Genes		3 interacting genes: HSP90AA1 PIK3CA SOX4	16 interacting genes: ADRB2 APBA1 APBA2 APBA3 COPS3 DENND1A DENND1B EGFR HNRNPD IKBKG PTEN RAB11FIP3 RCHY1 SDCBP2 SIRPA SUMO2
Entrez ID		3697	378
HPRD ID		00927	03107
Ensembl ID		ENSG00000055957	ENSG00000168374
Uniprot IDs		B7Z8B6 P19827	P18085
PDB IDs		6FPY 6FPZ	1Z6X
GO Terms Enriched among Interactors		Regulation Of Cell Projection Assembly Regulation Of Apoptotic Process Intracellular Transport Nuclear Export Nuclear Transport Nucleocytoplasmic Transport Protein Stabilization Endocytic Vesicle Lumen MRNA Binding Positive Regulation Of Lamellipodium Organization Positive Regulation Of Lamellipodium Assembly Regulation Of Lamellipodium Assembly Regulation Of Programmed Cell Death Cellular Localization Establishment Of Localization In Cell Regulation Of Lamellipodium Organization Protein Folding Chaperone Positive Regulation Of Establishment Of Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Glucose Stimulus CTP Binding DATP Binding Regulation Of Protein Localization Cellular Response To Virus Regulation Of Protein Stability Cellular Response To Carbohydrate Stimulus ERBB Signaling Pathway Response To Virus RNA Export From Nucleus Striated Muscle Contraction Regulation Of Gene Expression Positive Regulation Of Immune System Process Intracellular Glucose Homeostasis Regulation Of Macromolecule Biosynthetic Process Protein Transport Phospholipase D Activator Activity Positive Regulation Of Protein Localization Neurofibrillary Tangle Assembly UTP Binding Sulfonylurea Receptor Binding Unfolded Protein Binding Regulation Of Organelle Organization Response To Biphenyl Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Rho GDP-dissociation Inhibitor Binding Response To Butyrate Cellular Response To Hydrostatic Pressure Intracellular Chemical Homeostasis Regulation Of Establishment Of Protein Localization Response To Glucose	Dendritic Spine Amyloid-beta Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Size Positive Regulation Of Proteolysis Regulation Of Protein Metabolic Process Endocytic Recycling Regulation Of Macromolecule Metabolic Process In Utero Embryonic Development Chordate Embryonic Development Regulation Of Cell Communication Regulation Of Signaling Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Establishment Of Protein Localization Regulation Of Metabolic Process Chemical Synaptic Transmission Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Trans-synaptic Signaling Synaptic Signaling Regulation Of Protein Modification Process Vesicle-mediated Transport To The Plasma Membrane Phosphatidylinositol Phosphate Binding Cerebral Cortex Cell Migration Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cellular Localization Regulation Of Gene Expression Protein Transport Regulation Of Proteolysis Establishment Of Localization In Cell Protein Homodimerization Activity Cellular Response To Estradiol Stimulus Enzyme Binding Regulation Of Macromolecule Biosynthetic Process Response To Electrical Stimulus Positive Regulation Of Metabolic Process Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mini Excitatory Postsynaptic Potential Intracellular Transport Presynaptic Modulation Of Chemical Synaptic Transmission Locomotory Behavior