COLEC12 and ZBTB14

Data Source: HiPPIP (Novel)

		COLEC12	ZBTB14
Name		collectin subfamily member 12	zinc finger and BTB domain containing 14
Structure			No pdb structure
GO Annotations	Cellular Component	Collagen Trimer Plasma Membrane Membrane Endocytic Vesicle Membrane Extracellular Matrix	Nucleus Nucleoplasm Nucleolus Cytosol Aggresome
	Molecular Function	Scavenger Receptor Activity Protein Binding Galactose Binding Low-density Lipoprotein Particle Binding Carbohydrate Binding Pattern Recognition Receptor Activity Metal Ion Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Immune System Process Phagocytosis, Recognition Defense Response Immune Response Carbohydrate Mediated Signaling Defense Response To Bacterium Plasma Membrane Raft Organization Innate Immune Response	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Kidney Development Regulation Of Immune System Process Heart Valve Development Cardiac Septum Development Negative Regulation Of DNA-templated Transcription Coronary Vasculature Development
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Scavenging by Class A Receptors	None
GWAS		Bipolar disorder ( 20351715 ) Bipolar disorder or major depressive disorder ( 20351715 ) Blood protein levels ( 30072576 ) Coenzyme Q10 levels ( 27149984 ) Metabolic syndrome ( 29212154 ) Obesity-related traits ( 23251661 ) Schizophrenia x sex interaction ( 34099189 ) Smoking status (ever vs never smokers) ( 30643258 )	Cerebral amyloid deposition (PET imaging) ( 26252872 ) Lacunar stroke ( 33773637 )
Novel Interactors		3 novel interactors: EXOSC2 PTPN2 ZBTB14	10 novel interactors: AP4B1 ASXL3 B4GALT6 COLEC12 ITGB7 KCNAB3 PLAGL1 PTPN2 SLC4A1 TM9SF1
Interacting Genes		3 interacting genes: APP EXOC1 FBXO7	51 interacting genes: AP1M1 ATP5PO ATRIP BAZ2B BYSL C2orf68 CAPN6 CBX8 CDK16 CDKL3 CEP19 DDX6 EAF1 EIF1AD ENKD1 EPM2AIP1 FAM161A FAM90A1 GORASP2 INTS3 KAT5 MAD2L1BP MFAP1 MORF4L2 MRPL11 NAA10 NAA11 OGT PIN1 PNKP POLR2L PRMT1 RNASEH2B RNPS1 RPA1 RPA2 RPL9 RPS25 RPS7 SCNM1 SDCBP SNRPB2 SYT16 TCEANC TRIM55 TSTD2 TXN2 WNT9A ZBTB21 ZCCHC10 ZMAT2
Entrez ID		81035	7541
HPRD ID		06358	03674
Ensembl ID		ENSG00000158270	ENSG00000198081
Uniprot IDs		Q5KU26	B2R850 O43829
PDB IDs		2OX8	Not available
GO Terms Enriched among Interactors		Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome Lumen Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Interleukin-2-mediated Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Response To Endoplasmic Reticulum Stress Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Regulation Of Immune System Process Regulation Of Cell Activation Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Lipoprotein Particle Cytosol Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Leukocyte Activation Positive Regulation Of Protein Import Cell Activation Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Interleukin-4-mediated Signaling Pathway Regulation Of Positive Thymic T Cell Selection Negative Regulation Of Hemopoiesis Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Macrophage Colony-stimulating Factor Signaling Pathway Lewy Body Core Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Positive Regulation Of Small Molecule Metabolic Process Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of PERK-mediated Unfolded Protein Response	Nucleoplasm Nucleus Macromolecule Metabolic Process Nucleic Acid Metabolic Process Regulation Of Double-strand Break Repair Regulation Of DNA Repair Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Site Of Double-strand Break Protein N-terminal-serine Acetyltransferase Activity Nucleotide-excision Repair Protein Binding DNA Repair Regulation Of Cell Cycle Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination Mismatch Repair NatA Complex Protein-N-terminal Amino-acid Acetyltransferase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Acetylation Positive Regulation Of Double-strand Break Repair Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination G-rich Strand Telomeric DNA Binding RNA Processing MRNA Splicing, Via Spliceosome U2-type Precatalytic Spliceosome N-terminal Protein Amino Acid Acetylation Clathrin Adaptor Complex Organelle Assembly RNA Splicing, Via Transesterification Reactions DNA Replication Factor A Complex Cytoplasmic Translation RNA Metabolic Process DNA Metabolic Process Regulation Of Cell Cycle Process