ZNF436 and ZNF580

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZNF436	ZNF580
Name		zinc finger protein 436	zinc finger protein 580
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Chemotaxis Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-8 Production Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Hydrogen Peroxide
Pathways		Generic Transcription Pathway	None
GWAS		A body shape index ( 34021172 ) Estimated glomerular filtration rate ( 30604766 31015462 ) Glomerular filtration rate ( 29403010 ) Heel bone mineral density ( 30598549 ) Waist-hip index ( 34021172 )	No GWAS studies recorded
Interacting Genes		14 interacting genes: CCDC125 CCDC57 CLK2 CREB1 KDM1A KIF9 NTAQ1 OGT PRMT5 PRMT6 SUV39H1 TRIM55 TRIM63 ZNF580	27 interacting genes: ARHGEF6 BANP CCDC136 CYSRT1 FSD2 GOLGA6L9 HOMEZ IKZF1 KHDRBS3 KRT27 KRT34 KRT40 KRTAP10-7 KRTAP10-8 MDFI MTUS2 NBPF19 NOTCH2NLA PAX9 PSTPIP1 RAD54B SH3GL2 TRIM27 TRIP6 TSC22D4 XBP1 ZNF436
Entrez ID		80818	51157
HPRD ID		15793	18353
Ensembl ID		ENSG00000125945	ENSG00000213015
Uniprot IDs		A0AAA9YHR6 Q9C0F3	Q9UK33
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Circadian Rhythm Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Histone H4R3 Methyltransferase Activity Protein Modification Process Regulation Of Transcription By Glucose Protein-arginine N-methyltransferase Activity Rhythmic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Transferase Activity Identical Protein Binding Histone Methyltransferase Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Methyltransferase Activity Chromatin Organization Negative Regulation Of RNA Metabolic Process Methylation Negative Regulation Of Metabolic Process Regulation Of Gluconeogenesis Protein Metabolic Process Regulation Of Multicellular Organismal Process Chemotaxis To Arachidonate Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Glycolytic Process Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Protein-N-terminal Glutamine Amidohydrolase Activity Histone H2AR3 Methyltransferase Activity Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cardiac Muscle Tissue Development Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Multicellular Organism Growth Chromatin Remodeling Epigenetic Regulation Of Gene Expression Circadian Regulation Of Gene Expression Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Carbohydrate Catabolic Process P53 Binding Peptidyl-arginine N-methylation Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Protein-N-terminal Asparagine Amidohydrolase Activity Histone H3R2 Methyltransferase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of ATP Metabolic Process	Keratin Filament Intermediate Filament Identical Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process