FOSL1 and TAB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FOSL1	TAB2
Description		FOS like 1, AP-1 transcription factor subunit	TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Molecular Adaptor Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	In Utero Embryonic Development Toll-like Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Cellular Defense Response Vitellogenesis Positive Regulation Of Cell Population Proliferation Response To Wounding Response To Virus Gene Expression Cytokine-mediated Signaling Pathway Placenta Blood Vessel Development Integrated Stress Response Signaling Positive Regulation Of MiRNA Transcription Positive Regulation Of DNA-templated Transcription Initiation	Inflammatory Response Canonical NF-kappaB Signal Transduction Heart Development Response To Bacterium Negative Regulation Of Autophagy Response To Lipopolysaccharide Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Kinase Activity Protein K63-linked Ubiquitination
Pathways		NGF-stimulated transcription NGF-stimulated transcription	Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31959851) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 27863252 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 23128233) Psoriasis ( 28537254) Sum eosinophil basophil counts ( 27863252)	Breast cancer ( 22383897 29059683) Coronary artery disease ( 33020668) Diverticulitis ( 28585551) Dupuytren's disease ( 21732829 28886342) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		30 interacting genes: ABL1 ATF3 ATF4 ATXN1 BATF3 CALCOCO1 CCDC120 CEBPA CEBPE CEBPG CREB5 DDIT3 DNMT3L EP300 ERCC6 GCC1 JUN JUNB KIFC3 KPNA1 LDOC1 MAF MAFB NME7 PARVG PIN1 TAB2 TRIM24 USF1 WFDC1	44 interacting genes: APP CAMK2A CST9L EIF2AK2 EMILIN1 ERBB4 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 HSF2BP IKBKB IKBKG IRAK1 KRT85 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPIL3 PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TPM3 TRAF2 TRAF3IP1 TRAF6 TRIM45 TTN UBC UBE2I VIM VPS52 XIAP YWHAZ ZBTB16 ZFP64 ZNF143
Entrez ID		8061	23118
HPRD ID		00643	05483
Ensembl ID		ENSG00000175592	ENSG00000055208
Uniprot IDs		A0A0S2Z595 E9PKL5 E9PPX2 P15407	B4DIR9 Q9NYJ8
PDB IDs			2DAE 2WWZ 2WX0 2WX1 9AVT 9AVW
Enriched GO Terms of Interacting Partners?		Integrated Stress Response Signaling RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signaling Cassette Positive Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Regulation Of RNA Metabolic Process Myeloid Cell Differentiation Leukocyte Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cellular Response To Stress Regulation Of Primary Metabolic Process DNA-templated Transcription Positive Regulation Of Gene Expression Mononuclear Cell Differentiation Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Animal Organ Development Regulation Of Gene Expression Signal Transduction Identical Protein Binding Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Response To Stress Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Response To Nutrient Levels Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Biosynthetic Process Developmental Process	Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of JNK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Signaling Positive Regulation Of Defense Response Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Communication Identical Protein Binding Regulation Of Macromolecule Metabolic Process Protein Modification Process Positive Regulation Of Multicellular Organismal Process MyD88-dependent Toll-like Receptor Signaling Pathway Histone Deacetylase Complex Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-activating Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Innate Immune Response-activating Signaling Pathway Response To Other Organism
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