TFAP2D and SLAIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TFAP2D	SLAIN1
Description		transcription factor AP-2 delta	SLAIN motif family member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Cytoplasm Cytoskeleton Microtubule Plus-end
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Transcription By RNA Polymerase II Regulation Of Cell Population Proliferation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Inferior Colliculus Development	Microtubule Nucleation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization
Pathways		Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body mass index ( 29273807) Breast size ( 22747683) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Fruit consumption ( 32066663) Hand grip strength ( 29691431) Overweight status ( 25133637) Parahippocampal gyrus volume ( 31530798) Refractive error ( 32231278) Response to citalopram or escitalopram in depression ( 27622933) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcutaneous adipose tissue ( 29178545) Systolic blood pressure ( 28135244) Western dietary pattern ( 28644415)	Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Craniofacial microsomia ( 26853712) Metabolite levels ( 23823483)
Interacting Genes		64 interacting genes: ADAM12 ADAMTSL4 AGR2 AKAP8L BAG4 CAMK2A CARD10 CDPF1 CEP76 CIMIP2B CNFN CSNK2B CYSRT1 FAM168A GUCD1 GYS1 HOXD12 IKZF3 INCA1 KLHL20 KPRP KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-3 KRTAP15-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 MLH1 OIP5 PITX1 PLEKHG4 PRR22 PSMB4 RAD54L2 SIVA1 SLAIN1 SPMIP9 SPRY1 SSC4D TEPSIN TLE5 TNS2 TRAF1 TRIM42 TSC1 USP54 VPS37C ZBTB32 ZMYND12	50 interacting genes: AIRIM AKAP9 ARHGEF5 ARMC7 ATOSB BCAS2 CARD9 COX5B CPSF7 CRACR2A DDX6 DMRTB1 EFHC1 EXOSC8 FBXO7 FHL2 FHL3 FRS3 GOLGA1 HNRNPF HOMER3 HOXC8 HSF2BP KCTD9 KIF9 KRT31 LMO3 MAPRE1 MAPRE3 NDEL1 NTAQ1 NXF1 PATZ1 PAX9 PDLIM7 PFDN5 PRC1 PRPF31 PSMA3 QKI RBM10 RBM14 RBPMS RFPL3 SAXO4 SIAH1 TBC1D22B TFAP2D TSSK3 ZNF76
Entrez ID		83741	122060
HPRD ID		11627	13400
Ensembl ID		ENSG00000008197	ENSG00000139737
Uniprot IDs		Q7Z6R9	A0A0A0MSS3 A0A994J5K0 B7Z326 Q5T6P1 Q7L0J2 Q8ND83
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Protein Binding Keratinization Identical Protein Binding	Protein Binding Microtubule Organizing Center MRNA Splicing, Via Spliceosome Mitotic Spindle Astral Microtubule End MRNA Processing RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process MRNA Binding Identical Protein Binding Cytoskeleton Organization RNA Splicing Microtubule-based Process Cytoplasmic Stress Granule Membraneless Organelle Assembly RNA Processing Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Microtubule Cytoskeleton Organization Sperm Flagellum Regulation Of MRNA Processing Cytoplasm Nucleus Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Podosome Assembly Microtubule Binding Protein Localization To Microtubule Regulation Of Microtubule Polymerization Regulation Of Microtubule-based Process
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