PNPLA3 and FLT3

		PNPLA3	FLT3
Description		patatin like domain 3, 1-acylglycerol-3-phosphate O-acyltransferase	fms related receptor tyrosine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Lipid Droplet Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Plasma Membrane Endosome Membrane Membrane Protein-containing Complex Receptor Complex
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Lipoprotein Lipase Activity Phospholipase A2 Activity Triacylglycerol Lipase Activity Acylglycerol O-acyltransferase Activity Transferase Activity Acyltransferase Activity Hydrolase Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Binding Lysophosphatidic Acid Acyltransferase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor Receptor Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Growth Factor Binding Nuclear Glucocorticoid Receptor Binding Protein-containing Complex Binding Phosphatidylinositol 3-kinase Activator Activity
	Biological Process	Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phospholipid Biosynthetic Process Response To Sucrose Lipid Catabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Insulin Stimulus Lipid Droplet Organization Triglyceride Acyl-chain Remodeling Acylglycerol Acyl-chain Remodeling White Fat Cell Differentiation Lipid Homeostasis Cellular Response To 3,3',5-triiodo-L-thyronine	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Cell Migration Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Lymphocyte Proliferation Protein Autophosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation Liver Regeneration
Pathways		Acyl chain remodeling of DAG and TAG	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation FLT3 mutants bind TKIs STAT5 activation downstream of FLT3 ITD mutants KW2449-resistant FLT3 mutants semaxanib-resistant FLT3 mutants crenolanib-resistant FLT3 mutants gilteritinib-resistant FLT3 mutants lestaurtinib-resistant FLT3 mutants midostaurin-resistant FLT3 mutants pexidartinib-resistant FLT3 mutants ponatinib-resistant FLT3 mutants quizartinib-resistant FLT3 mutants sorafenib-resistant FLT3 mutants sunitinib-resistant FLT3 mutants tandutinib-resistant FLT3 mutants linifanib-resistant FLT3 mutants tamatinib-resistant FLT3 mutants Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs			Sorafenib Sunitinib XL999 Tandutinib Linifanib Lestaurtinib Midostaurin Ponatinib Nintedanib Pacritinib Tivozanib Fostamatinib Gilteritinib Brigatinib Fedratinib Amuvatinib Quizartinib Pexidartinib Pralsetinib
Diseases			Acute myeloid leukemia (AML)
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alanine aminotransferase levels ( 34315874 33547301 33339817 31219225 30718733) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Alanine transaminase levels ( 29403010) Alcohol-related hepatocellular carcinoma ( 34902334) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 31219225 34315874 29403010 33547301 33339817) Cirrhosis ( 31815349) Cirrhosis (alcohol related) ( 26482880 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Gout ( 33832965) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494 27863252) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatic lipid content in extreme obesity ( 25246029) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514 22001757) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 29403010) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 21909109) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Nonalcoholic fatty liver disease ( 29271184 21423719 29385134 24531328 22719876 34841290 32298765 31311600) Nonalcoholic steatohepatitis ( 32298765) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Percent liver fat ( 34128465) Platelet count ( 27863252 29403010 32888494) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494 28957414 27863252) Serum uric acid levels ( 30993211) Total cholesterol levels ( 30275531 33339817 31217584) Total triglycerides levels ( 26690388) Triacylglycerol 56:6 levels ( 31560688) Type 2 diabetes ( 29632382 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528)	Apolipoprotein A1 levels ( 32203549) Autoimmune thyroid disease ( 32581359) Basophil count ( 32888494) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 29403010 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494) Psoriasis ( 25854761) Rapid automised naming of digits ( 30741946) Serum total protein levels ( 29403010) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Tourette syndrome ( 30818990) White blood cell count ( 27863252 32888494) White blood cell count (monocyte) ( 28158719)
Interacting Genes		3 interacting genes: AKT2 LINC00839 SNX27	18 interacting genes: CBL CBLB CTNNB1 ERBB2 FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN11 PTPN12 PTPN6 SH3BP2 SLA SOCS1 SRC UBE2L6
Entrez ID		80339	2322
HPRD ID		12430	00635
Ensembl ID		ENSG00000100344	ENSG00000122025
Uniprot IDs		Q9NST1	P36888
PDB IDs			1RJB 3QS7 3QS9 4RT7 4XUF 5X02 6IL3 6JQR 7QDP 7ZV9 8XB1
Enriched GO Terms of Interacting Partners?		Early Endosome Cellular Response To High Light Intensity Positive Regulation Of Cytoplasmic Translational Initiation Response To High Light Intensity Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Retinal Cell Apoptotic Process Positive Regulation Of Cap-dependent Translational Initiation Retinal Rod Cell Apoptotic Process Peripheral Nervous System Myelin Maintenance Vascular Endothelial Growth Factor Receptor Activity Common Myeloid Progenitor Cell Proliferation Pro-B Cell Differentiation Myeloid Progenitor Cell Differentiation Phosphatidylinositol 3-kinase Activator Activity Postsynaptic Recycling Endosome Establishment Of Natural Killer Cell Polarity Postsynaptic Early Endosome Cellular Response To Hormone Stimulus Negative Regulation Of PERK-mediated Unfolded Protein Response Lymphoid Progenitor Cell Differentiation Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Mammary Gland Epithelial Cell Differentiation Response To Light Intensity Positive Regulation Of Glycogen Biosynthetic Process Regulation Of PERK-mediated Unfolded Protein Response Glycogen Biosynthetic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Nuclear Glucocorticoid Receptor Binding WASH Complex Vascular Endothelial Growth Factor Signaling Pathway Protein Kinase Activity Localization Within Membrane Polysaccharide Biosynthetic Process Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Retromer Complex Molecular Function Activator Activity Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Protein Targeting To Membrane Regulation Of Synapse Maturation Regulation Of Glycogen Biosynthetic Process Liver Regeneration Regulation Of Protein Targeting To Membrane Kinase Activity	Phosphotyrosine Residue Binding Receptor Tyrosine Kinase Binding Regulation Of Lymphocyte Activation Ephrin Receptor Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Activation ERBB Signaling Pathway Negative Regulation Of Immune System Process Regulation Of Mononuclear Cell Proliferation Regulation Of T Cell Activation Regulation Of Leukocyte Proliferation Cellular Response To Growth Factor Stimulus SH3 Domain Binding Response To Growth Factor Negative Regulation Of Leukocyte Activation Regulation Of MAPK Cascade Positive Regulation Of Lymphocyte Activation Negative Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Leukocyte Activation Positive Regulation Of Cell Activation Immune System Process Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Neutrophil Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Neutrophil Activation T Cell Receptor Signaling Pathway T Cell Costimulation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Cell Adhesion
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