EDEM3 and METTL13

		EDEM3	METTL13
Description		ER degradation enhancing alpha-mannosidase like protein 3	methyltransferase 13, eEF1A N-terminus and K55
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Hydrolase Activity Metal Ion Binding	Catalytic Activity Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Response To Unfolded Protein Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Ubiquitin-dependent Glycoprotein ERAD Pathway Endoplasmic Reticulum Mannose Trimming	Methylation
Pathways		ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31511532 31630189) Waist circumference adjusted for body mass index ( 34021172)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Diffusing capacity of carbon monoxide ( 30694715) Platelet distribution width ( 32888494)
Interacting Genes		2 interacting genes: TRA TXNDC5	5 interacting genes: SNRPA THAP1 TRAF2 UBC VPS52
Entrez ID		80267	51603
HPRD ID		10724	13821
Ensembl ID		ENSG00000116406	ENSG00000010165
Uniprot IDs		A0A8J8YX80 Q9BZQ6	C4B4C6 Q8N6R0
PDB IDs			5WCJ
Enriched GO Terms of Interacting Partners?		Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Alpha-beta T Cell Receptor Complex Immune Response To Tumor Cell T Cell Mediated Cytotoxicity T Cell Receptor Complex Beta-catenin Destruction Complex Nuclear Envelope Lumen S100 Protein Binding Response To Growth Hormone Intracellular Organelle Lumen Protein Disulfide Isomerase Activity Protein-disulfide Reductase Activity Protein-lysine N-methyltransferase Activity	Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Ubiquitin-dependent Glycoprotein ERAD Pathway GARP Complex EARP Complex Ectodermal Cell Differentiation Spliceosomal SnRNP Complex Sphingolipid Binding IRE1-TRAF2-ASK1 Complex CD27 Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex
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