METTL13 and SNRPA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		METTL13	SNRPA
Description		methyltransferase 13, eEF1A N-terminus and K55	small nuclear ribonucleoprotein polypeptide A
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP U4/U6 X U5 Tri-snRNP Complex Spliceosomal SnRNP Complex Ribonucleoprotein Complex
	Molecular Function	Catalytic Activity Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding U1 SnRNA Binding Identical Protein Binding U1 SnRNP Binding
	Biological Process	Methylation	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs			Malonic acid
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Diffusing capacity of carbon monoxide ( 30694715) Platelet distribution width ( 32888494)	Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Hematocrit ( 27863252) melanoma-derived growth regulatory protein levels ( 25147954) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		5 interacting genes: SNRPA THAP1 TRAF2 UBC VPS52	84 interacting genes: ACAA2 APOBEC3C BAG4 CDKN2A CEBPA CFL1 CHTOP CIRBP CISD1 DAPK1 DAZAP1 DDIT4L DDX17 DDX39B DMRTB1 ENOX2 EXOSC8 FBXO7 FUBP1 GABPB1 HNRNPA0 HNRNPLL HNRNPR IL7R LENG8 LHX4 LNX1 LYAR MBNL1 MBNL2 METTL13 MRPL15 MTUS2 NDUFAF3 NXF1 OTX2 PAPOLA PCBP1 PCBP2 PCBP3 PEG10 PRPF6 PRR3 PTBP1 PTBP2 PUF60 QKI RASAL3 RBFOX2 RBM10 RBM11 RBM22 RBM3 RBM42 RBM4B RBM7 RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 RPL23 SDCBP SF1 SFPQ SMAD5 SNRPA1 SNRPN SRSF8 SUGP1 TFIP11 TIAL1 TLE5 TNFAIP8L1 TRIM27 TRIR U2AF2 UBC WBP4 YTHDF1 YTHDF3 ZC3H10 ZC3HAV1 ZCCHC13
Entrez ID		51603	6626
HPRD ID		13821	01658
Ensembl ID		ENSG00000010165	ENSG00000077312
Uniprot IDs		C4B4C6 Q8N6R0	P09012
PDB IDs		5WCJ	1AUD 1DRZ 1DZ5 1FHT 1M5K 1M5O 1M5P 1M5V 1NU4 1OIA 1SJ3 1SJ4 1SJF 1U6B 1URN 1VBX 1VBY 1VBZ 1VC0 1VC5 1VC6 1ZZN 2A3J 2NZ4 2OIH 2OJ3 2U1A 3BO2 3BO3 3BO4 3CUL 3CUN 3EGZ 3G8S 3G8T 3G96 3G9C 3HHN 3IIN 3IRW 3IWN 3K0J 3L3C 3MUM 3MUR 3MUT 3MUV 3MXH 3P49 3PGW 3R1H 3R1L 3UCU 3UCZ 3UD3 3UD4 4C4W 4PR6 4PRF 4W90 4W92 4YB1 5DDO 5DDP 5DDQ 5DDR 5FJ4 6LAS 6LAU 6LAX 6LAZ 6QX9 6SQN 6SQQ 6SQT 6SQV 6SR7 6XH0 6XH1 6XH2 6XH3 7AEP 7B0Y 7D7V 7DLZ 7DWH 7LHX 7QR3 7QR4 7VPX 8GXB 8GXC 8JY0
Enriched GO Terms of Interacting Partners?		Embryonic Ectodermal Digestive Tract Development TORC2 Complex Disassembly TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Ubiquitin-dependent Glycoprotein ERAD Pathway GARP Complex EARP Complex Ectodermal Cell Differentiation Spliceosomal SnRNP Complex Sphingolipid Binding IRE1-TRAF2-ASK1 Complex CD27 Signaling Pathway Tumor Necrosis Factor Receptor Superfamily Complex	RNA Binding Nucleic Acid Binding Regulation Of RNA Splicing MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Binding Regulation Of MRNA Splicing, Via Spliceosome RNA Processing RNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process Nucleus MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleoplasm Positive Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Gene Expression Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of MRNA Metabolic Process Nuclear Speck Negative Regulation Of RNA Splicing Ribonucleoprotein Complex Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cytoplasmic Stress Granule Protein Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process
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