PAAF1 and PSMC4

Number of citations of the paper that reports this interaction (PubMedID 15831487)
38

Data Source:
HPRD (in vivo)

		PAAF1	PSMC4
Description		proteasomal ATPase associated factor 1	proteasome 26S subunit, ATPase 4
Image		No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Cytosol	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Proteasome Accessory Complex Ciliary Basal Body
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Proteasome-activating Activity
	Biological Process		Blastocyst Development Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		Proteasome assembly Proteasome assembly	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Dimensional psychopathology (Cognitive) ( 29496196)
Interacting Genes		6 interacting genes: ANXA7 PSMC1 PSMC4 PSMC6 TK1 UBLCP1	17 interacting genes: CEBPA FILNC1 NPM1 NR1I3 OGT PAAF1 PSMC2 PSMC3 PSMC5 PSMD10 RNF2 RORB SUMO2 TRAP1 UBASH3A UBLCP1 ZFAND1
Entrez ID		80227	5704
HPRD ID		07761	04085
Ensembl ID		ENSG00000175575	ENSG00000013275
Uniprot IDs		F5H0C4 Q9BRP4	A8K2M0 P43686
PDB IDs			2DVW 5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Proteasome-activating Activity Proteasome Regulatory Particle, Base Subcomplex Proteasome Accessory Complex Proteasome Complex Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ATP Hydrolysis Activity Regulation Of Protein Catabolic Process Regulation Of Proteasome Assembly Proteasomal Protein Catabolic Process ATP Binding Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Modification-dependent Protein Catabolic Process Thymidine Kinase Activity Proteasome Regulatory Particle Binding Protein Catabolic Process DNA Synthesis Involved In Mitotic DNA Replication Proteolysis Involved In Protein Catabolic Process Nucleotide Binding Cytosolic Proteasome Complex Positive Regulation Of Inclusion Body Assembly Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Thymidine Biosynthetic Process Positive Regulation Of Protein Metabolic Process Catabolic Process Thymidine Metabolic Process Nucleus Chromaffin Granule Membrane Deoxyribonucleoside Monophosphate Biosynthetic Process Response To Phorbol 13-acetate 12-myristate Macromolecule Catabolic Process Proteasome Regulatory Particle Negative Regulation Of ATP-dependent Activity Pyrimidine Nucleoside Metabolic Process Proteolysis Inclusion Body Regulation Of Inclusion Body Assembly Regulation Of Protein-containing Complex Assembly Blastocyst Development Regulation Of Protein Metabolic Process Regulation Of ATP-dependent Activity Vesicle Membrane Pyrimidine-containing Compound Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process	Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Proteasome Regulatory Particle, Base Subcomplex Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Proteasome Complex Proteasome-activating Activity Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Proteasome Accessory Complex Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process ATP Hydrolysis Activity Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Macrophage Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA
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