SPG11 and PAK6

		SPG11	PAK6
Description		SPG11 vesicle trafficking associated, spatacsin	p21 (RAC1) activated kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Cytosol Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Cell Projection Synapse	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction
	Molecular Function	Protein Binding Protein Kinase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Protein Import Into Nucleus Intracellular Protein Transport Lysosome Organization Chemical Synaptic Transmission Axonogenesis Neuromuscular Junction Development Memory Axo-dendritic Transport Intracellular Protein Localization Corticospinal Tract Morphogenesis Protein Catabolic Process Cholesterol Efflux Vesicle Transport Along Microtubule Synaptic Vesicle Transport Axon Extension Skeletal Muscle Fiber Development Neuron Apoptotic Process Localization Within Membrane Motor Behavior Phagosome-lysosome Fusion Involved In Apoptotic Cell Clearance Walking Behavior Motor Neuron Apoptotic Process Autophagosome Organization Regulation Of Store-operated Calcium Entry	Regulation Of DNA-templated Transcription Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Cellular Response To Starvation Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension
Pathways			Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Anti-Toxoplasma gondii IgG seropositivity ( 30610941) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		1 interacting genes: SERTAD3	19 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 HSF2BP LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RHOJ RHOV SEMA3B SNX2 TPD52L1
Entrez ID		80208	56924
HPRD ID		07963	06426
Ensembl ID		ENSG00000104133	ENSG00000137843
Uniprot IDs		A0A804HID9 Q96JI7	Q9NQU5
PDB IDs			2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?			Intracellular Signal Transduction Anatomical Structure Morphogenesis Developmental Process Cellular Response To Estrogen Stimulus Protein Kinase Binding Supramolecular Fiber Organization Regulation Of Mitotic Cell Cycle Protein-containing Complex Protein Serine Kinase Activity Glutamatergic Synapse Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Cell Communication Regulation Of Signal Transduction Regulation Of Cell Cycle Phase Transition Developmental Growth Involved In Morphogenesis Regulation Of Developmental Process Regulation Of Developmental Growth Regulation Of Intracellular Signal Transduction Estrogen Response Element Binding Prostate Gland Growth Response To Estrogen Mitotic Nuclear Membrane Disassembly Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Cell Cycle Process Protein Kinase Activity Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle Cellular Developmental Process Regulation Of Locomotion Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Protein Localization To Kinetochore Regulation Of Reproductive Process Positive Regulation Of Cell Migration Developmental Growth Regulation Of Growth Regulation Of MiRNA Transcription Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Reproductive Process Membrane Disassembly Nuclear Membrane Disassembly Leukocyte Differentiation GTP Binding Cell-cell Signaling Cellular Response To Oxygen-containing Compound Regulation Of Apoptotic Signaling Pathway
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