NUP85 and DYNC1LI1

Number of citations: 0 (PubMedID 10893222)
Data Source: HPRD (in vivo)

		NUP85	DYNC1LI1
Name		nucleoporin 85	dynein cytoplasmic 1 light intermediate chain 1
Structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Actin Cytoskeleton Membrane Nuclear Pore Outer Ring Nuclear Membrane Ciliary Basal Body	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Endosome Centrosome Cytosol Cytoskeleton Cytoplasmic Dynein Complex Microtubule Plasma Membrane Membrane Dynein Complex Endocytic Vesicle Membrane Secretory Granule Membrane Recycling Endosome Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding Structural Constituent Of Nuclear Pore	Nucleotide Binding RNA Binding Protein Binding ATP Binding GTP Binding GDP Binding Protein-macromolecule Adaptor Activity Dynein Heavy Chain Binding Molecular Adaptor Activity
	Biological Process	MRNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Chemotaxis Protein Transport Lamellipodium Assembly Positive Regulation Of DNA-templated Transcription Macrophage Chemotaxis MRNA Transport Nephron Development	Microtubule Cytoskeleton Organization Microtubule-based Movement Cell Division Regulation Of Vesicle-mediated Transport Early Endosome To Recycling Endosome Transport Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways		ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation SARS-CoV-2 activates/modulates innate and adaptive immune responses	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
GWAS		Systemic sclerosis ( 31672989 )	Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Low density lipoprotein cholesterol levels ( 33339817 )
Interacting Genes		6 interacting genes: DYNC1LI1 EEF1G GET4 PIK3R1 PRKACA VIM	11 interacting genes: BRCA2 CEBPA IKBKG NOP56 NUP85 OGT PGAM2 RAB4A REL RUFY1 SLC25A21-AS1
Entrez ID		79902	51143
HPRD ID		01363	10917
Ensembl ID		ENSG00000125450	ENSG00000144635
Uniprot IDs		F5H0W7 J3KT10 Q9BW27	B3KM42 E9PHI6 Q9Y6G9
PDB IDs		5A9Q 7PEQ 7R5J 7R5K	6B9H 6PSD 6PSE