ZAN and TFPI2

Data Source: HiPPIP (Novel)

		ZAN	TFPI2
Name		zonadhesin	tissue factor pathway inhibitor 2
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Membrane Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent	Serine-type Endopeptidase Inhibitor Activity Extracellular Matrix Structural Constituent Peptidase Inhibitor Activity
	Biological Process	Cell Adhesion Binding Of Sperm To Zona Pellucida Cell-cell Adhesion	Blood Coagulation Hemostasis
Pathways		None	Developmental Lineage of Pancreatic Ductal Cells
GWAS		Bipolar disorder ( 31043756 ) Heel bone mineral density ( 30598549 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 ) Waist circumference adjusted for body mass index ( 34021172 ) White matter hyperintensities ( 32358547 )	Heart rate response to recovery post exercise (10 sec) ( 29497042 ) Heart rate response to recovery post exercise (20 sec) ( 29497042 ) Heart rate response to recovery post exercise (30 sec) ( 29497042 ) Heart rate response to recovery post exercise (40 sec) ( 29497042 ) Heart rate response to recovery post exercise (50 sec) ( 29497042 )
Novel Interactors		2 novel interactors: RASA4 TFPI2	1 novel interactors: ZAN
Interacting Genes		None recorded	5 interacting genes: F11 KLKB1 PLG SKIL SMURF2
Entrez ID		7455	7980
HPRD ID		03846	08962
Ensembl ID		ENSG00000146839	ENSG00000105825
Uniprot IDs		B4DYT6 Q9Y493	P48307
PDB IDs		Not available	1ZR0
GO Terms Enriched among Interactors		None	Positive Regulation Of Fibrinolysis Regulation Of Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Coagulation Blood Coagulation Hemostasis Plasminogen Activation Serine-type Peptidase Activity Regulation Of Wound Healing Serine-type Endopeptidase Activity Fibrinolysis Regulation Of Response To Wounding Protein Processing Zymogen Activation Regulation Of Body Fluid Levels Protein Maturation SMAD Binding Negative Regulation Of BMP Signaling Pathway Proteolysis Peptidase Activity Serine-type Aminopeptidase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Extracellular Space Factor XII Activation Regulation Of Multicellular Organismal Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Trans-synaptic Signaling By BDNF Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Protein Domain Specific Binding Protein Antigen Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Fibrinolysis Trans-synaptic Signaling, Modulating Synaptic Transmission Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Trophoblast Giant Cell Differentiation Lens Fiber Cell Differentiation Negative Regulation Of Multicellular Organismal Process Regulation Of Cellular Response To Growth Factor Stimulus Plasma Membrane