CHPF and TUBA4B

		CHPF	TUBA4B
Description		chondroitin polymerizing factor	tubulin alpha 4b
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Mitochondrial Matrix Golgi Apparatus Cytosol Membrane Golgi Cisterna Membrane	Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	Protein Binding Acetylgalactosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Metal Ion Binding Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity	Nucleotide Binding Structural Constituent Of Cytoskeleton GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Chondroitin Sulfate Proteoglycan Biosynthetic Process	Cytoskeleton Organization Microtubule-based Process
Pathways		CS-GAG biosynthesis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			CYT997
Diseases
GWAS			Platelet distribution width ( 27863252) Serum folate levels ( 29953918)
Interacting Genes		11 interacting genes: ARHGEF5 BTRC EXOSC10 EXOSC6 LCOR LINC00839 NKX3-1 PIN1 PRKN SKIL SMAD9	1 interacting genes: GRIN1
Entrez ID		79586	80086
HPRD ID		10829	18242
Ensembl ID		ENSG00000123989	ENSG00000243910
Uniprot IDs		Q8IZ52	Q9H853
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Ligase Activator Activity Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Poly(A)-dependent SnoRNA 3'-end Processing Nuclear MRNA Surveillance Nucleolar Exosome (RNase Complex) Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process Beta-catenin Binding Ubiquitin-specific Protease Binding Regulation Of Dopamine Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Histone Deacetylase Binding Protein K6-linked Ubiquitination Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Exocytosis Regulation Of Phosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Nuclear Estrogen Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Androgen Secretion Regulation Of Intrinsic Apoptotic Signaling Pathway MADS Box Domain Binding Negative Regulation Of Spontaneous Neurotransmitter Secretion Regulation Of Protein Targeting To Mitochondrion Cis-trans Isomerase Activity RNA Surveillance Nuclear RNA Surveillance Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Regulation Of Primary Metabolic Process Leukocyte Cell-cell Adhesion Integrin AlphaL-beta2 Complex Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Dorsal Aorta Development Positive Regulation Of Retrograde Transport, Endosome To Golgi SCF Ubiquitin Ligase Complex Negative Regulation Of Intralumenal Vesicle Formation Positive Regulation Of Protein Linear Polyubiquitination	Response To Glycine Glycine-gated Cation Channel Activity Propylene Metabolic Process N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase Activity NMDA Glutamate Receptor Activity Glutamate Binding Acetylgalactosaminyltransferase Activity Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase Activity NMDA Selective Glutamate Receptor Complex Glycine Binding Excitatory Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Neurotransmitter Receptor Complex Ligand-gated Sodium Channel Activity Positive Regulation Of Calcium Ion Transport Into Cytosol Protein Heterotetramerization Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Chondroitin Sulfate Proteoglycan Biosynthetic Process Regulation Of Calcium Ion Transport Into Cytosol Synaptic Cleft Chondroitin Sulfate Proteoglycan Metabolic Process Positive Regulation Of Excitatory Postsynaptic Potential Protein Heterooligomerization Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Excitatory Synapse Ligand-gated Ion Channel Signaling Pathway Terminal Bouton Regulation Of Reactive Oxygen Species Biosynthetic Process Glutamate Receptor Signaling Pathway Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Visual Behavior Visual Learning Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Reactive Oxygen Species Metabolic Process Excitatory Postsynaptic Potential Synaptic Membrane Response To Amyloid-beta Positive Regulation Of Calcium Ion Transmembrane Transport Golgi Cisterna Membrane Proteoglycan Biosynthetic Process Regulation Of Synaptic Transmission, Glutamatergic Amyloid-beta Binding Calcium Channel Activity Proteoglycan Metabolic Process Calcium Ion Transmembrane Import Into Cytosol Protein Tetramerization Associative Learning
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