MAIP1 and APOC4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MAIP1	APOC4
Name		matrix AAA peptidase interacting protein 1	apolipoprotein C4
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle
	Molecular Function	Protein Binding Ribosome Binding	Lipid Transporter Activity Protein Binding
	Biological Process	Protein Insertion Into Mitochondrial Inner Membrane From Matrix Calcium Import Into The Mitochondrion Protein Insertion Into Mitochondrial Membrane Mitochondrial Calcium Ion Homeostasis	Lipid Metabolic Process Lipid Transport Lipid Storage Triglyceride Homeostasis
Pathways		Processing of SMDT1	VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
GWAS		Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268 ) Sleep duration ( 30846698 )	Alzheimer's disease (onset between ages 58 and 79) ( 30979435 ) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Apolipoprotein A1 levels ( 32203549 ) Carotid intima media thickness (maximum) ( 31801372 ) Carotid intima media thickness (mean) ( 31801372 ) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321 ) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321 ) Cerebrospinal AB1-42 levels in normal cognition ( 29274321 ) Cerebrospinal fluid AB1-42 levels ( 29274321 ) Cerebrospinal fluid p-tau levels ( 29274321 ) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321 ) Cerebrospinal fluid t-tau levels ( 29274321 ) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321 ) HDL cholesterol levels ( 32203549 ) Hippocampal volume ( 29274321 ) Hippocampal volume in Alzheimer's disease dementia ( 29274321 ) LDL cholesterol ( 20864672 19060906 18802019 18193044 18193043 ) Logical memory (delayed recall) ( 29274321 ) Logical memory (immediate recall) ( 29274321 ) Quantitative traits ( 19197348 ) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659 )
Novel Interactors		1 novel interactors: PPIL3	1 novel interactors: APOE
Interacting Genes		5 interacting genes: APOC1 APOC2 APOC4 APP H4C7	24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1
Entrez ID		79568	346
HPRD ID		07994	02848
Ensembl ID		ENSG00000162972	ENSG00000267467
Uniprot IDs		Q8WWC4	P55056
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Lipoprotein Metabolic Process Acylglycerol Homeostasis Triglyceride Homeostasis Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Intermediate-density Lipoprotein Particle Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Regulation Of Receptor-mediated Endocytosis Chylomicron Phospholipid Efflux Low-density Lipoprotein Particle Negative Regulation Of Lipoprotein Particle Clearance Lipid Homeostasis Negative Regulation Of Cholesterol Transport Molecular Function Activator Activity Plasma Lipoprotein Particle Clearance Cholesterol Efflux Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Phospholipid Metabolic Process Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Negative Regulation Of Lipid Transport Regulation Of Triglyceride Metabolic Process Chemical Homeostasis Regulation Of Fatty Acid Biosynthetic Process Lipid Transport Regulation Of Endocytosis Regulation Of Small Molecule Metabolic Process Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Negative Regulation Of Endocytosis Sterol Transport Negative Regulation Of Phosphatidylcholine Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Phospholipid Transport Homeostatic Process Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Lipid Metabolic Process Protein-containing Complex Organization Regulation Of Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process	Virion Assembly Membrane Mitochondrion Mitochondrion Organization Mitochondrial Inner Membrane Inner Mitochondrial Membrane Organization MICOS Complex Mitochondrial Crista Junction SAM Complex MIB Complex Host-mediated Perturbation Of Viral Genome Replication Mitochondrial Membrane Cristae Formation Host-mediated Perturbation Of Viral Process Mitochondrial Outer Membrane Negative Regulation Of Platelet Activation Positive Regulation Of ERAD Pathway Mitochondrial Calcium Ion Homeostasis Host-mediated Perturbation Of Symbiont Process Mitochondrial Membrane Organization Modulation Of Process Of Another Organism Extrinsic Apoptotic Signaling Pathway Regulation Of ERAD Pathway Negative Regulation Of Phospholipid Efflux Lipoprotein Metabolic Process Negative Regulation Of Postsynaptic Membrane Organization Positive Regulation Of Lipid Transport Across Blood-brain Barrier Host-mediated Activation Of Viral Process Negative Regulation Of Lipid Transport Across Blood-brain Barrier Regulation Of Cellular Response To Very-low-density Lipoprotein Particle Stimulus Metal Chelating Activity Intermediate-density Lipoprotein Particle Clearance Positive Regulation Of Coagulation Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity Palmitoleoyltransferase Activity Protein Palmitoleylation Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Pyroptotic Inflammatory Response 4 Iron, 4 Sulfur Cluster Binding Organelle Organization Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Positive Regulation Of Presynaptic Membrane Organization Chylomicron Remnant Lipid Transport Involved In Lipid Storage Lipoprotein Particle Protein Binding Regulation Of Platelet Activation