PAGR1 and DCTPP1

Data Source: HiPPIP (Novel)

		PAGR1	DCTPP1
Name		PAXIP1 associated glutamate rich protein 1	dCTP pyrophosphatase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Nuclear Estrogen Receptor Binding	Nucleotide Binding Magnesium Ion Binding Protein Binding Pyrophosphatase Activity Hydrolase Activity Pyrimidine Deoxyribonucleotide Binding Identical Protein Binding Metal Ion Binding Nucleoside Triphosphate Diphosphatase Activity DCTP Diphosphatase Activity
	Biological Process	DNA Repair DNA Recombination DNA Damage Response Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Cycle G1/S Phase Transition	DCTP Catabolic Process Nucleoside Triphosphate Catabolic Process DNA Protection DTTP Catabolic Process
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	Interconversion of nucleotide di- and triphosphates
GWAS		No GWAS studies recorded	Urinary sodium excretion ( 31409800 )
Novel Interactors		1 novel interactors: DCTPP1	10 novel interactors: ARMC5 GDPD3 PAGR1 PRR14 RUSF1 SLX1B VKORC1 ZNF668 ZNF747 ZNF768
Interacting Genes		4 interacting genes: APP ESR1 NCOA1 PAXIP1	12 interacting genes: APP FMR1 FXR1 FXR2 LNX1 NIF3L1 NOA1 NTAQ1 PSMA1 SDCBP SPG21 USP7
Entrez ID		79447	79077
HPRD ID		14647	18310
Ensembl ID		ENSG00000280789	ENSG00000179958
Uniprot IDs		Q9BTK6	Q9H773
PDB IDs		Not available	7MU5
GO Terms Enriched among Interactors		Chromatin Remodeling Negative Regulation Of MiRNA Transcription Chromatin Organization Mating Behavior Estrogen Receptor Signaling Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Reproductive Behavior Nuclear Estrogen Receptor Binding Positive Regulation Of Nitric Oxide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Neuron Differentiation Chromatin Binding Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-binding Transcription Factor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose DTTP Catabolic Process DCTP Diphosphatase Activity DCTP Catabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Estradiol Male Gonad Development Acetylcholine Receptor Activator Activity Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Labyrinthine Layer Morphogenesis Pyrimidine Deoxyribonucleotide Binding PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Translation Regulator Activity Growth Cone Filopodium Postsynapse RNA Strand Annealing Activity Presynaptic Modulation Of Chemical Synaptic Transmission Intracellular Membraneless Organelle Protein Heterodimerization Activity Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing Regulation Of Synaptic Plasticity Regulation Of Receptor Internalization Cytoplasmic Ribonucleoprotein Granule Presynapse Collateral Sprouting Cytoplasmic Stress Granule DNA Repair Positive Regulation Of Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization MRNA Transport MRNA 3'-UTR Binding Regulation Of MiRNA-mediated Gene Silencing Regulation Of Post-transcriptional Gene Silencing Dentate Gyrus Development Neuron Maturation Regulation Of Nucleobase-containing Compound Metabolic Process Neuron Projection Frizzled Binding Dendritic Spine RNA Transport Positive Regulation Of Translation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Intracellular Transport Of Viral Material Interleukin-5 Receptor Complex Protein-N-terminal Glutamine Amidohydrolase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Adrenal Cortex Development Regulation Of Long-term Synaptic Potentiation Chromosome Regulation Of RNA Metabolic Process Regulation Of Translation Molecular Condensate Scaffold Activity