DCAF10 and OTUD1

Number of citations of the paper that reports this interaction (PubMedID 33898171)
58

Data Source:
BioGRID (enzymatic study)

		DCAF10	OTUD1
Description		DDB1 and CUL4 associated factor 10	OTU deubiquitinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Protein Ubiquitination	Proteolysis Protein Deubiquitination Protein K63-linked Deubiquitination
Pathways		Neddylation	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) Loneliness (linear analysis) ( 27629369) Reticulocyte count ( 32888494)	Obesity (early onset extreme) ( 23563609) Tourette syndrome ( 30818990)
Interacting Genes		7 interacting genes: ADRB2 CUL4B LHX4 OTUD1 SRPK2 TCEA2 UBC	7 interacting genes: AKT1 CARD9 DCAF10 PRDX4 RIPK1 UBC YAP1
Entrez ID		79269	220213
HPRD ID		08319	19512
Ensembl ID		ENSG00000122741	ENSG00000165312
Uniprot IDs		A0A0A0MQT4 Q5QP82	Q5VV17
PDB IDs			4BOP
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Lymphocyte Apoptotic Process T Cell Apoptotic Process Peptidyl-serine Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Organ Growth Negative Regulation Of Apoptotic Signaling Pathway Response To Ketone Negative Regulation Of Cilium Assembly Leukocyte Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Modification Process Apoptotic Signaling Pathway Protein Phosphorylation Regulation Of TRNA Methylation Enterocyte Differentiation Response To Oxidative Stress Phosphorylation Regulation Of Apoptotic Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Regulation Of Cilium Assembly Positive Regulation Of Protein Localization To Endoplasmic Reticulum Cytokine-mediated Signaling Pathway Regulation Of Notch Signaling Pathway Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage Positive Regulation Of Gene Expression Protein Autophosphorylation TRNA (guanine-N7)-methylation Regulation Of Organ Growth Response To Tumor Necrosis Factor Cellular Response To Rapamycin Positive Regulation Of Defense Response Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Catabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of JNK Cascade Positive Regulation Of DNA-binding Transcription Factor Activity Ripoptosome Assembly Death Domain Binding Ripoptosome Assembly Involved In Necroptotic Process
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