SLC34A2 and GUCA2A

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SLC34A2	GUCA2A
Name		solute carrier family 34 member 2	guanylate cyclase activator 2A
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Membrane Apical Plasma Membrane Brush Border Membrane Vesicle	Extracellular Region
	Molecular Function	Sodium:phosphate Symporter Activity Protein Binding Symporter Activity Sodium Ion Binding Phosphate Ion Binding	Hormone Activity Protein Binding Guanylate Cyclase Activator Activity
	Biological Process	In Utero Embryonic Development Monoatomic Ion Transport Sodium Ion Transport Phosphate Ion Transport Intracellular Phosphate Ion Homeostasis Sodium Ion Transmembrane Transport Response To Estrogen Sodium-dependent Phosphate Transport Transmembrane Transport	Signal Transduction
Pathways		Type II Na+/Pi cotransporters Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) Surfactant metabolism Defective SLC34A2 causes PALM	Digestion
Diseases		Non-small cell lung cancer	None
GWAS		Metabolite levels ( 23823483 )	No GWAS studies recorded
Interacting Genes		19 interacting genes: AIG1 ERG28 FXYD6-FXYD2 GUCA2A JAGN1 LHFPL5 PLN PNLIPRP1 RTP2 SLC30A3 SLC35A1 SLC39A7 STRIT1 TEX264 TMEM128 TMEM239 TMEM42 TRARG1 TSPO2	15 interacting genes: ASPH FFAR2 GJA8 GOLM1 GUCY2C NEMP1 SGTA SLC34A2 TMEM179B TMEM237 TMEM31 TMEM86B TRAM1 UBQLN1 UBQLN2
Entrez ID		10568	2980
HPRD ID		07251	00767
Ensembl ID		ENSG00000157765	ENSG00000197273
Uniprot IDs		O95436	Q02747
PDB IDs		Not available	1GNA 1GNB 1O8R
GO Terms Enriched among Interactors		Regulation Of ATPase-coupled Calcium Transmembrane Transporter Activity Membrane Response To Zinc Ion Endoplasmic Reticulum Membrane Regulation Of Cardiac Muscle Cell Contraction Circadian Sleep/wake Cycle, Sleep Regulation Of ATP-dependent Activity Phospholamban Complex Sarcoplasmic Reticulum Membrane Regulation Of Calcium Ion Import Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Zinc Ion Transport Zinc Ion Transmembrane Transporter Activity Zinc Ion Transmembrane Transport Zinc Ion Import Into Synaptic Vesicle CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport 5-aminolevulinic Acid Import Across Plasma Membrane 5-aminolevulinic Acid Transmembrane Transporter Activity Regulation Of The Force Of Heart Contraction By Cardiac Conduction Calcium Ion-transporting ATPase Complex Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Positive Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cardiac Muscle Cell Contraction	Membrane Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Protein Insertion Into ER Membrane Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity D-lysine 5,6-aminomutase Activity Response To Endoplasmic Reticulum Stress Peptidyl-aspartic Acid 3-dioxygenase Activity Plasma Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Protein Targeting To Membrane TRC Complex Protein Insertion Into Membrane Negative Regulation Of G Protein-coupled Receptor Internalization Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Autophagosome Assembly