TMEM43 and FDFT1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TMEM43	FDFT1
Gene Name		transmembrane protein 43	farnesyl-diphosphate farnesyltransferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Endoplasmic Reticulum Lumen Golgi Apparatus	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Self-association	Farnesyl-diphosphate Farnesyltransferase Activity Oxidoreductase Activity Squalene Synthase Activity
	Biological Process	Nuclear Membrane Organization	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Isoprenoid Biosynthetic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Farnesyl Diphosphate Metabolic Process Oxidation-reduction Process
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Cholesterol biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005)
Protein-Protein Interactions		2 interactors: FDFT1 SIAH1	6 interactors: ANXA5 ARL6IP1 FAM101A RUVBL2 SHPRH TMEM43
Entrez ID		79188	2222
HPRD ID		15541	01694
Ensembl ID		ENSG00000170876	ENSG00000079459
Uniprot IDs		Q9BTV4	B4DT56 B4DWP0 B7Z1J3 P37268 Q6IAX1
PDB IDs			1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC
Enriched GO Terms of Interacting Partners?		Farnesyl Diphosphate Metabolic Process	Negative Regulation Of Estrogen Receptor Binding Transcriptional Activation By Promoter-enhancer Looping Nuclear Membrane Organization Establishment Of Protein Localization To Chromatin DNA Conformation Change Negative Regulation Of Receptor Binding Protein Localization To Chromatin Histone H2A Acetylation
Tagcloud ?		arrhythmias arrhythmogenic arvc cardiomyopathy compensated confer definite desmosomal discrepancy dsc2 dsg2 dsp familial fibrofatty fulfilled genetics helps jup missense myocardium penetrance pkp2 poison relatives spanish stop sudden truncating ventricular	abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Difference) ?		arrhythmias arrhythmogenic arvc cardiomyopathy compensated confer definite desmosomal discrepancy dsc2 dsg2 dsp familial fibrofatty fulfilled genetics helps jup missense myocardium penetrance pkp2 poison relatives spanish stop sudden truncating ventricular	abca1 biosynthesis brains cassette cholesterol debated extensively fdps genetically idi1 ldr lipids microarray mvd mvk notably nsdhl oligomeric oligomers plaques principal qpcr sc4mol steroid steroids toxic unexpected unresolved verified
Tagcloud (Intersection) ?