FSD1 and PEX14

Number of citations of the paper that reports this interaction (PubMedID 35044719)
104

Data Source:
BioGRID (unspecified method)

		FSD1	PEX14
Description		fibronectin type III and SPRY domain containing 1	peroxisomal biogenesis factor 14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Cleavage Furrow	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex Peroxisomal Importomer Complex
	Molecular Function	Microtubule Binding Identical Protein Binding	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Protein Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Beta-tubulin Binding
	Biological Process	Cytoplasmic Microtubule Organization Regulation Of Cytokinesis Cell Division Regulation Of Cell Division Regulation Of Mitotic Spindle Organization	Protein Monoubiquitination Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To Reactive Oxygen Species Peroxisome Transport Along Microtubule Protein Unfolding Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly
Pathways			E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Pursuit maintenance gain ( 29064472)	Asthma ( 34103634 32296059 27182965) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 27117709 23535729 23535733) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)
Interacting Genes		4 interacting genes: CDK5 NAP1L1 PEX14 PPP1R16A	24 interacting genes: ACACB AFTPH CAMTA1 CBFA2T2 CENPK COPS4 FSD1 GET3 HDAC1 KDM5D MARF1 MED8 MTNR1A NEDD9 NFE2 NFKBIL1 OGT PEX19 PEX26 PEX5 PEX7 SMARCC2 TONSL ZHX1
Entrez ID		79187	5195
HPRD ID		17021	03477
Ensembl ID		ENSG00000105255	ENSG00000142655
Uniprot IDs		M0R366 Q9BTV5	O75381
PDB IDs			2W84 2W85 4BXU 9GAG
Enriched GO Terms of Interacting Partners?		Receptor Metabolic Process Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Presynaptic Cytosolic Calcium Concentration Peroxisome Transport Along Microtubule Acetylcholine Receptor Activator Activity ErbB-2 Class Receptor Binding Protein Kinase 5 Complex Negative Regulation Of Synaptic Plasticity Cerebellar Cortex Formation Peroxisomal Importomer Complex Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Negative Regulation Of Synaptic Vesicle Exocytosis Microtubule Binding Establishment Of Organelle Localization ErbB-3 Class Receptor Binding Protein Import Into Peroxisome Matrix, Substrate Release Myosin Phosphatase Regulator Activity Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Cerebellar Cortex Development Negative Regulation Of Protein Export From Nucleus Negative Regulation Of Calcium Ion-dependent Exocytosis Signaling Receptor Inhibitor Activity Protein Import Into Peroxisome Matrix, Receptor Recycling Regulation Of Neurogenesis Histone Chaperone Activity Protein Unfolding Layer Formation In Cerebral Cortex Corpus Callosum Development Receptor Catabolic Process Organelle Localization Behavioral Response To Cocaine Schwann Cell Development Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Transmission, Dopaminergic Microtubule Cytoskeleton Organization Regulation Of Nervous System Development Establishment Of Protein Localization To Peroxisome Protein Import Into Peroxisome Matrix	Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Protein Import Into Peroxisome Membrane Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Peroxisomal Membrane Peroxisome Membrane Targeting Sequence Binding Nucleoplasm Intracellular Protein Transmembrane Transport Protein Carrier Chaperone Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Nucleus Fatty Acid Oxidation Establishment Of Protein Localization To Membrane Protein Transmembrane Transport Protein Localization To Organelle Lipid Oxidation Nucleosome Disassembly Sin3-type Complex Protein-DNA Complex Disassembly Protein-containing Complex Negative Regulation Of Stem Cell Population Maintenance Receptor Recycling Circadian Rhythm Chromatin Organization Lipid Modification Regulation Of Androgen Receptor Signaling Pathway Protein-containing Complex Disassembly Lactic Acid Secretion Intracellular Aspartate Homeostasis Nucleosomal DNA Binding Establishment Of Protein Localization To Organelle Peroxisome Matrix Targeting Signal-2 Binding Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Receptor Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Peroxisomal Matrix Malonyl-CoA Biosynthetic Process Protein-containing Complex Organization Acetyl-CoA Carboxylase Activity Krueppel-associated Box Domain Binding Positive Regulation Of Immunological Synapse Formation Fatty Acid Beta-oxidation Peroxisome Matrix Targeting Signal-1 Binding
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