FTO

Description		FTO alpha-ketoglutarate dependent dioxygenase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding Ferrous Iron Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Transferase Activity Oxidative RNA Demethylase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity MRNA N6-methyladenosine Dioxygenase Activity TRNA Demethylase Activity
	Biological Process	Temperature Homeostasis DNA Alkylation Repair Regulation Of Lipid Storage SnRNA Processing Regulation Of Multicellular Organism Growth RNA Repair Regulation Of Respiratory System Process Adipose Tissue Development MRNA Destabilization Regulation Of White Fat Cell Proliferation Regulation Of Brown Fat Cell Differentiation
Pathways		Reversal of alkylation damage by DNA dioxygenases
Drugs		Artenimol
Diseases		Growth retardation, developmental delay, coarse facies, and early death Type II diabetes mellitus
GWAS		Adiposity ( 21706003) Adolescent idiopathic scoliosis ( 31417091) Adult body size ( 32376654) Age at adiposity rebound ( 31840077) Alanine aminotransferase levels ( 33547301) Alcohol consumption ( 31358974) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Appendicular lean mass ( 33097823) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Beef consumption ( 32066663) Biomedical quantitative traits ( 19396169) Blood glucose levels ( 31928498) Blood urea nitrogen levels ( 29403010 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI at 7 years old ( 31575865) BMI at 8 years old ( 31575865) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body fat percentage ( 26833246 28270201 31453325) Body fat percentage variance ( 31453325) Body mass in chronic obstructive pulmonary disease ( 21037115) Body mass index ( 17434869 18454148 19079260 19079261 20935630 22982992 23563607 23583978 23669352 24064335 24348519 24861553 25673413 25953783 26426971 26961502 28270201 28448500 28552196 28892062 29381148 30045251 31453325 31513605 31888951) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast cancer ( 23535729 23535733 27117709 29059683) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast size ( 27182965) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Caffeine consumption from coffee ( 33287642) Caffeine consumption from tea ( 33287642) Childhood body mass index ( 26604143 33045005) Chromosomal aberration frequency (chromosome type) ( 31586183) Chronotype ( 30696823) circulating leptin levels ( 26833098 32917775) Coffee consumption ( 31046077) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Dietary macronutrient intake ( 23636237 29988085) End-stage kidney disease ( 31178898) Eyebrow thickness ( 26926045) Facial morphology ( 31763980) Femur bone mineral density x serum urate levels interaction ( 34046847) Fish- and plant-related diet ( 32066663) Glycated hemoglobin levels ( 28898252) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) Heel bone mineral density ( 28869591 30598549) Height adjusted BMI ( 25044758) High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference ( 25673412 28552196 31453325) Hip circumference variance ( 31453325) Intake of total sugars ( 31005972) LDL cholesterol levels ( 32203549) Lean body mass ( 28552196 28724990) Liver enzyme levels (alanine transaminase) ( 33972514) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) in asthma ( 32989782) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Melanoma ( 23455637 28212542) Menarche (age at onset) ( 21102462 25231870 27182965) Metabolic syndrome ( 22399527 31589552) Morning person ( 30696823) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-oily fish consumption ( 32066663) Nonalcoholic fatty liver disease ( 34841290) Number of sexual partners ( 30643258) Obese vs. thin ( 30677029) Obesity ( 19151714 21544081 21552555 23563607) Obesity (early onset extreme) ( 18159244 20421936 23563609) Obesity (extreme) ( 19553259 30677029 31852448) Obesity-related traits ( 17658951) Obstructive sleep apnea ( 33243845) Oily fish consumption ( 32066663) Opioid dependence (time to event) ( 34124712) Osteoarthritis ( 22763110) Pork consumption ( 32066663) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Pure non-grapefruit juice consumption ( 31046077) Red cell distribution width ( 28957414) Red vs. brown/black hair color ( 30531825) Relative sugar intake ( 32393786) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Sasang constitutional medicine type (So-Eum) ( 25888059) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Sex hormone-binding globulin levels ( 22675492) Sleep duration (long sleep) ( 30846698) Strenuous sports or other exercises ( 29899525) Subcutaneous adipose tissue ( 22589738 27918534) Subscapular skin fold thickness ( 31513605) Sugar-sweetened beverage consumption ( 31046077) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 31928498) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924) Triglyceride levels ( 28334899 32902719) Triglycerides ( 24097068 30275531) Trunk fat mass ( 28552196) Type 2 diabetes ( 17463248 17463249 17554300 18372903 19056611 20581827 22693455 22885922 23209189 24509480 26818947 26961502 28869590 30054458 30297969 30718926 32499647) Type 2 diabetes nephropathy ( 30566433) Type 2 diabetes nephropathy including microalbuminuria ( 30566433) Urate levels ( 31578528) Urinary sodium excretion ( 31409800) Urolithiasis ( 30975718) Waist circumference ( 19557197 25673412 28552196 31453325 31928498) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412 28552196) Walking pace ( 33128006) Weight ( 19079260 28552196)
Novel Interacting Genes		1 novel interacting genes: CXCR4
Interacting Genes		20 interacting genes: AIRIM ANKRD11 CCDC57 CLP1 DTX2 EFEMP2 GNG13 GPANK1 IL16 KLHL38 MAD2L2 MORN3 NXF1 OGT PRDM6 SHC3 TNPO2 TTC19 USP20 ZNF77
Entrez ID		79068
HPRD ID		19057
Ensembl ID		ENSG00000140718
Uniprot IDs		A0A1B0GTC5 B3KU60 Q99770 Q9C0B1
PDB IDs		3LFM 4CXW 4CXX 4CXY 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7 4QHO 4QKN 4ZS2 4ZS3 5DAB 5F8P 5ZMD 6AEJ 6AK4 6AKW 7CKK 7E8Z 7WCV 8IT9 9KNI
Enriched GO Terms of Interacting Partners?
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