CENPO and ERI3

Number of citations of the paper that reports this interaction (PubMedID 19447967)
24

Data Source:
BioGRID (two hybrid)

		CENPO	ERI3
Description		centromere protein O	ERI1 exoribonuclease family member 3
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body Mis6-Sim4 Complex
	Molecular Function	Protein Binding	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Chromosome Segregation Centromere Complex Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body mass index ( 29273807 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cognitive function ( 28093568) Coronary artery disease ( 29212778) Height ( 23563607 28552196 25282103) Multiple sclerosis ( 24076602) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Trunk fat mass ( 28552196) Type 1 diabetes ( 21980299) Waist circumference adjusted for body mass index ( 34021172)	Anxiety ( 33859377) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)
Interacting Genes		6 interacting genes: CEP170P1 DCDC2 ERI3 FOS FOSB NECAB2	6 interacting genes: CENPO CPEB2 FNDC3B PRNP SHANK3 YTHDF1
Entrez ID		79172	79033
HPRD ID		14414	15175
Ensembl ID		ENSG00000138092	ENSG00000117419
Uniprot IDs		Q9BU64	B4DEX5 B4DN03 O43414
PDB IDs		7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	2XRI 7K05 7K06 7K07 7LPY 7LPZ 7LQ0
Enriched GO Terms of Interacting Partners?		Response To Corticosterone Response To Progesterone Response To Mineralocorticoid Response To Prolactin Response To Ethanol Double-stranded DNA Binding Conditioned Taste Aversion Female Pregnancy Response To Calcium Ion Response To CAMP Medium-term Memory Response To Glucocorticoid Cellular Response To Prolactin Cellular Response To Calcium Ion Axoneme Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Adenosine Receptor Signaling Pathway A2A Adenosine Receptor Binding Response To Purine-containing Compound Response To Corticosteroid Type 5 Metabotropic Glutamate Receptor Binding Cellular Response To Metal Ion Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation Response To Mechanical Stimulus Response To Gravity Response To Ketone Response To Steroid Hormone Kinocilium Skeletal Muscle Cell Proliferation Cellular Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Glutamate Receptor Signaling Pathway Mucociliary Clearance Myoblast Proliferation Cellular Response To Parathyroid Hormone Stimulus Response To Phorbol 13-acetate 12-myristate Response To Alcohol Cilium Assembly Regulation Of Glutamate Receptor Signaling Pathway Axonemal Dynein Complex Response To Xenobiotic Stimulus Transcription By RNA Polymerase II Cilium Organization Response To Parathyroid Hormone Response To Forskolin Neural Retina Development Response To Metal Ion Behavioral Response To Cocaine Response To Morphine Negative Regulation Of Receptor Internalization	Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Memory Regulation Of Synaptic Plasticity Dendritic Spine Organization Learning Or Memory Neuron Projection Organization Postsynapse Organization Cognition Type 8 Metabotropic Glutamate Receptor Binding Ribosome Binding Mis6-Sim4 Complex Negative Regulation Of Cytoplasmic Translational Elongation Modulation Of Chemical Synaptic Transmission Guanylate Kinase-associated Protein Clustering Cellular Component Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Postsynapse Organization Negative Regulation Of Dendritic Spine Maintenance Cupric Ion Binding Regulation Of Cell Projection Organization Type 5 Metabotropic Glutamate Receptor Binding FHF Complex Learning Centromere Complex Assembly Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Translational Elongation ATP-dependent Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Manchette Assembly Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Protein Localization To Perinuclear Region Of Cytoplasm Vocal Learning Neuron Spine Cuprous Ion Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Observational Learning Negative Regulation Of Cytoplasmic Translation Postsynaptic Density Microtubule Binding Dendritic Spine Maintenance Nervous System Process Postsynaptic Specialization Assembly
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