CENPO and ERI3

Number of citations of the paper that reports this interaction (PMID 19447967)
10

Data Source:
BioGRID (two hybrid)

		CENPO	ERI3
Gene Name		centromere protein O	ERI1 exoribonuclease family member 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleoplasm Cytosol	Nucleolus Cytoplasm
	Molecular Function		3'-5'-exoribonuclease Activity Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Nucleosome Assembly CENP-A Containing Nucleosome Assembly	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Pathways		Mitotic Prometaphase Chromosome Maintenance Nucleosome assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Height ( 23563607) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		5 interactors: CENPP CEP170P1 ERI3 FOS NECAB2	2 interactors: CENPO PRNP
Entrez ID		79172	79033
HPRD ID		14414	15175
Ensembl ID		ENSG00000138092	ENSG00000117419
Uniprot IDs		Q9BU64	B4DEX5 B4DN03 O43414
PDB IDs			2XRI
Enriched GO Terms of Interacting Partners?		Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Conditioned Taste Aversion RRNA 3'-end Processing Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Sleep Response To Gravity Maturation Of 5.8S RRNA Response To Immobilization Stress CENP-A Containing Nucleosome Assembly Positive Regulation Of Osteoclast Differentiation RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Histone Exchange Response To Corticosterone DNA Replication-independent Nucleosome Assembly Response To Mineralocorticoid Centromere Complex Assembly Cellular Response To Calcium Ion Response To Progesterone Positive Regulation Of Myeloid Leukocyte Differentiation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway SMAD Protein Signal Transduction Response To Cold Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Skeletal Muscle Cell Differentiation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway DNA Methylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway ATP-dependent Chromatin Remodeling Toll-like Receptor 3 Signaling Pathway Regulation Of Osteoclast Differentiation	Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of Interleukin-17 Production Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Activated T Cell Proliferation Negative Regulation Of Interleukin-2 Production Cellular Copper Ion Homeostasis Negative Regulation Of T Cell Receptor Signaling Pathway Response To Copper Ion Copper Ion Homeostasis Protein Complex Assembly CENP-A Containing Nucleosome Assembly Histone Exchange Negative Regulation Of Interferon-gamma Production DNA Replication-independent Nucleosome Assembly Regulation Of Activated T Cell Proliferation Regulation Of Potassium Ion Transmembrane Transport Cell Cycle Regulation Of Calcium-mediated Signaling Regulation Of T Cell Receptor Signaling Pathway Centromere Complex Assembly Response To Cadmium Ion Regulation Of Potassium Ion Transport Negative Regulation Of T Cell Proliferation ATP-dependent Chromatin Remodeling Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Cellular Component Assembly Regulation Of Interferon-gamma Production Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleosome Assembly Cellular Response To Metal Ion Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Chromatin Assembly Cellular Response To Inorganic Substance Nucleosome Organization Regulation Of T Cell Proliferation Cell Cycle Arrest Transition Metal Ion Homeostasis Chromatin Assembly Or Disassembly Negative Regulation Of Leukocyte Activation Protein-DNA Complex Assembly Chromatin Remodeling DNA Packaging
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