GID4 and ELAC2

		GID4	ELAC2
Description		GID complex subunit 4 homolog	elaC ribonuclease Z 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Mitochondrial Nucleoid
	Molecular Function	Ubiquitin Protein Ligase Activity	RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity TRNA-specific Ribonuclease Activity Hydrolase Activity 3'-tRNA Processing Endoribonuclease Activity Metal Ion Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	TRNA Processing TRNA Decay TRNA 3'-end Processing Mitochondrial TRNA Processing Mitochondrial TRNA 3'-end Processing
Pathways		Regulation of pyruvate metabolism	tRNA processing in the nucleus tRNA processing in the mitochondrion rRNA processing in the mitochondrion tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Myocardial infarction ( 33532862) Schizophrenia ( 25056061 29483656) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Squamous cell lung carcinoma ( 28604730)
Interacting Genes		3 interacting genes: MAEA UBE2H ZMYND19	10 interacting genes: ASCC2 CTBP1 CTBP2 CUX1 GOLM1 NDUFA7 RING1 RNF10 SMAD2 SUMO2
Entrez ID		79018	60528
HPRD ID		12683	05641
Ensembl ID		ENSG00000141034	ENSG00000006744
Uniprot IDs		B3KXL6 K4DI96 Q8IVV7	A0A0S2Z5M8 Q9BQ52
PDB IDs		6CCR 6CCT 6CCU 6CD8 6CD9 6CDC 6CDG 6WZX 6WZZ 7NSC 7Q4Y 7Q50 7SLZ 7U3E 7U3F 7U3G 7U3H 7U3I 7U3J 7U3K 7U3L 8V1P	8CBL 8RR1 8RR3 8RR4 8Z0P 8Z1F 8Z1G 9EY0 9EY1 9EY2
Enriched GO Terms of Interacting Partners?		Enucleate Erythrocyte Development TRNA-specific Ribonuclease Activity 3'-tRNA Processing Endoribonuclease Activity Mitochondrial TRNA 3'-end Processing Actomyosin Contractile Ring GID Complex Mitochondrial RNA 3'-end Processing Macromolecule Catabolic Process Ubiquitin-protein Transferase Activity TRNA Decay TRNA 3'-end Processing Mitochondrial TRNA Processing	Ribosome-associated Ubiquitin-dependent Protein Catabolic Process White Fat Cell Differentiation Viral Genome Replication Regulation Of DNA-templated Transcription NAD Binding DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Transcription Coregulator Binding Regulation Of RNA Metabolic Process Transcription Corepressor Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Transcription Repressor Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Homomeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Ubiquitin Protein Ligase Activity Cytosolic Ribosome RQC-trigger Complex GABA-ergic Synapse Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Ligase Complex
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