MANF and RRP9

Data Source: HiPPIP (Novel)

		MANF	RRP9
Name		mesencephalic astrocyte derived neurotrophic factor	ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Sarcoplasmic Reticulum Sarcoplasmic Reticulum Lumen	Nucleus Nucleoplasm Nucleolus Box C/D Methylation Guide SnoRNP Complex Small-subunit Processome Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Growth Factor Activity Lipid Binding Sulfatide Binding	RNA Binding Protein Binding SnoRNA Binding U3 SnoRNA Binding
	Biological Process	Vasoconstriction Of Artery Involved In Ischemic Response To Lowering Of Systemic Arterial Blood Pressure Response To Unfolded Protein Neuron Projection Development ATF6-mediated Unfolded Protein Response Dopaminergic Neuron Differentiation Regulation Of Response To Endoplasmic Reticulum Stress	RRNA Processing Ribosomal Small Subunit Biogenesis
Pathways		Platelet degranulation	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
GWAS		Depressive symptom (appetite changes) (binary trait) ( 31530331 ) Depressive symptoms (binary sum-score) ( 31530331 ) Depressive symptoms (sum-score) ( 31530331 ) Diverticular disease ( 30177863 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: RRP9 TWF2	2 novel interactors: MANF STAB1
Interacting Genes		1 interacting genes: ZDHHC17	4 interacting genes: CSNK2A1 RAP2A SIRT7 SMURF1
Entrez ID		7873	9136
HPRD ID		03558	08827
Ensembl ID		ENSG00000145050	ENSG00000114767
Uniprot IDs		A8K878 P55145	O43818
PDB IDs		2KVD 2KVE 2W51	4J0W 4JXM 7MQ8 7MQ9 7MQA
GO Terms Enriched among Interactors		Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Box C/D Methylation Guide SnoRNP Complex Regulation Of Microvillus Length Anion Binding Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity U3 SnoRNA Binding Actin Filament Depolymerization Regulation Of Cell Projection Size Barbed-end Actin Filament Capping Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity SnoRNA Binding Actin Monomer Binding Positive Regulation Of Lamellipodium Assembly Protein Lipidation Positive Regulation Of Lamellipodium Organization Actin Filament Capping Regulation Of Lamellipodium Assembly Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Axon Extension Protein Depolymerization	Protein Targeting To Vacuole Involved In Autophagy Regulation Of Cellular Response To Stress Protein Localization To Vacuole Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Vasoconstriction Of Artery Involved In Ischemic Response To Lowering Of Systemic Arterial Blood Pressure Histone H3K18 Deacetylase Activity, NAD-dependent NAD-dependent Protein-lysine Depropionylase Activity Protein Deglutarylation Protein-succinyllysine Desuccinylase Activity Protein Depropionylation Nucleolus Organizer Region Protein-glutaryllysine Deglutarylase Activity Engulfment Of Target By Autophagosome Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell Growth Regulation Of Ubiquitin-dependent Protein Catabolic Process Vacuolar Transport Intracellular Signal Transduction Positive Regulation Of Aggrephagy Positive Regulation Of Microvillus Assembly Protein Targeting Sulfatide Binding Activin Receptor Binding Regulation Of DNA Repair Regulation Of Anatomical Structure Morphogenesis Endolysosome ATF6-mediated Unfolded Protein Response NAD-dependent Protein Lysine Deacetylase Activity Substrate Localization To Autophagosome Positive Regulation Of Growth Positive Regulation Of RRNA Processing R-loop Processing Rap Protein Signal Transduction Regulation Of Microvillus Assembly Sarcoplasmic Reticulum Lumen Wnt Signaling Pathway Double-strand Break Repair Via Classical Nonhomologous End Joining Aggrephagy Regulation Of Cellular Component Organization Signal Transduction Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Establishment Of Protein Localization To Organelle Positive Regulation Of Systemic Arterial Blood Pressure Low-density Lipoprotein Particle Receptor Activity Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Regulation Of RRNA Processing Protein Deacetylation Protein Methyltransferase Activity