MANF

Description		mesencephalic astrocyte derived neurotrophic factor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Sarcoplasmic Reticulum Sarcoplasmic Reticulum Lumen
	Molecular Function	RNA Binding Protein Binding Growth Factor Activity Lipid Binding Sulfatide Binding
	Biological Process	Vasoconstriction Of Artery Involved In Ischemic Response To Lowering Of Systemic Arterial Blood Pressure Response To Unfolded Protein Neuron Projection Development ATF6-mediated Unfolded Protein Response Dopaminergic Neuron Differentiation Regulation Of Response To Endoplasmic Reticulum Stress
Pathways		Platelet degranulation
Drugs
Diseases
GWAS		Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Diverticular disease ( 30177863)
Novel Interacting Genes		2 novel interacting genes: RRP9 TWF2
Interacting Genes		1 interacting genes: ZDHHC17
Entrez ID		7873
HPRD ID		03558
Ensembl ID		ENSG00000145050
Uniprot IDs		A8K878 P55145
PDB IDs		2KVD 2KVE 2W51
Enriched GO Terms of Interacting Partners?		Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Box C/D Methylation Guide SnoRNP Complex Regulation Of Microvillus Length Anion Binding Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity U3 SnoRNA Binding Actin Filament Depolymerization Regulation Of Cell Projection Size Barbed-end Actin Filament Capping Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity SnoRNA Binding Actin Monomer Binding Positive Regulation Of Lamellipodium Assembly Protein Lipidation Positive Regulation Of Lamellipodium Organization Actin Filament Capping Regulation Of Lamellipodium Assembly Negative Regulation Of Actin Filament Depolymerization Positive Regulation Of Axon Extension Protein Depolymerization
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