BSND and STX8

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		BSND	STX8
Name		barttin CLCNK type accessory subunit beta	syntaxin 8
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Basolateral Plasma Membrane Protein-containing Complex	Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Plasma Membrane Endomembrane System Membrane SNARE Complex Vesicle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Chloride Channel Activity Protein Binding Chloride Channel Regulator Activity	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Chloride Transport Sensory Perception Of Sound Chloride Transmembrane Transport	Intracellular Protein Transport Vesicle Fusion Early Endosome To Late Endosome Transport Vesicle Docking Cellular Response To Type II Interferon Regulation Of Protein Localization To Plasma Membrane
Pathways		Stimuli-sensing channels	None
Diseases		Bartter syndrome	None
GWAS		Allergic rhinitis ( 25085501 ) Carotid intima media thickness x smoking interaction ( 32117412 ) Coronary artery disease ( 32469254 33020668 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Mitochondrial DNA copy number ( 30704525 )	Blood protein levels ( 30072576 ) Borderline personality disorder ( 28632202 ) Brain morphology (MOSTest) ( 32665545 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931 ) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507 )
Interacting Genes		28 interacting genes: ADIPOQ APOL2 APP ARFIP1 BMP10 CDIPT CERT1 COL4A5 COL8A2 CSGALNACT2 CTSA ECPAS FATE1 GAD2 IGFBP5 JAGN1 MYG1 PBX3 PLSCR2 PTPN9 SLC30A8 SPG21 STX8 TBRG4 THAP4 TMEM60 VAMP3 ZFPL1	84 interacting genes: ACVR1 AMIGO1 AQP2 AQP6 ARL13B ASGR2 BCL2L13 BIK BSND CALM1 CD300E CD79A CERS4 CLDN9 CLN8 COPA CPLX4 CREB3 CREB3L1 DHRS9 EBP ELOVL4 ERGIC3 FAM174A FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GORAB GPR151 GPR152 GPR42 GPX8 JAGN1 JSRP1 KCNMB1 LMNA MCEE MCL1 MFF MGST2 MGST3 MMGT1 MS4A3 MTERF3 NAPA NAPG NCR3LG1 NDUFAF1 NDUFAF2 NSF PEX12 PSCA RETREG3 RNASEK SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC22A2 SLC35H1 SSMEM1 STAR STMN4 STX1A STX2 STX7 TGFBR1 TMED8 TMEM14B TMEM179B TMEM205 TMEM237 TMEM86B TMPPE TMPRSS2 TSPAN12 VPS11 VPS18 VTI1B WDR91
Entrez ID		7809	9482
HPRD ID		05914	05012
Ensembl ID		ENSG00000162399	ENSG00000170310
Uniprot IDs		Q5VU50 Q8WZ55	Q9UNK0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Amyloid-beta Complex Lipoprotein Metabolic Process Response To Purine-containing Compound Growth Cone Lamellipodium Collateral Sprouting Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Recycling Endosome Trans-Golgi Network Membrane Amylin Binding Neuron Maturation Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Response To Cytokine Regulation Of Protein Localization Regulation Of Protein Transport Endoplasmic Reticulum Locomotory Behavior Response To CAMP Golgi Apparatus Endoplasmic Reticulum Lumen Positive Regulation Of CAMP/PKA Signal Transduction Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Extracellular Matrix Structural Constituent Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Skeletal Muscle Hypertrophy Posterior Compartment Specification Anterior Compartment Pattern Formation Regulation Of Cellular Localization Mitochondrial MRNA Processing Regulation Of Hormone Secretion Response To Type II Interferon SNAP Receptor Activity Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Response To Glucose Positive Regulation Of Glycogen (starch) Synthase Activity Response To Monosaccharide Phosphatidylinositol-4-phosphate Binding Amide Transport Intermembrane Sphingolipid Transfer CDP-diacylglycerol-inositol 3-phosphatidyltransferase Activity Negative Regulation Of Retrograde Transport, Endosome To Golgi Peroxynitrite Isomerase Activity Insulin Metabolic Process Early Endosome Negative Regulation Of Secretion By Cell Regulation Of System Process	Membrane Syntaxin Binding Endoplasmic Reticulum Membrane SNARE Binding Membrane Fusion SNARE Complex Organelle Localization By Membrane Tethering Membrane Docking Protein Binding Vesicle Docking Intra-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Protein Transport Organelle Fusion Chloride Channel Inhibitor Activity Vesicle Fusion Vesicle-mediated Transport Organelle Membrane Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Endomembrane System SNARE Complex Disassembly Soluble NSF Attachment Protein Activity Membrane Organization Transmembrane Transport Cellular Localization Endoplasmic Reticulum Neurotransmitter Transport Neurotransmitter Reuptake Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Glutathione Peroxidase Activity Establishment Of Protein Localization Intracellular Transport Transforming Growth Factor Beta Receptor Activity, Type I Leukotriene-C4 Synthase Activity Protein Transport Presynaptic Active Zone Membrane Norepinephrine Uptake Neurotransmitter Uptake Plasma Membrane Golgi Vesicle Transport Activin Receptor Complex Activin Receptor Activity, Type I CORVET Complex Lysosomal Membrane Renal Water Transport Voltage-gated Potassium Channel Complex Serotonin Uptake Norepinephrine Transport Protein-containing Complex Disassembly