ZNF200 and PPARGC1B

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		ZNF200	PPARGC1B
Gene Name		zinc finger protein 200	peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Mitochondrion Mediator Complex
	Molecular Function	Molecular_function Nucleic Acid Binding Metal Ion Binding	Nucleotide Binding RNA Polymerase II Transcription Cofactor Activity RNA Binding Transcription Factor Binding Estrogen Receptor Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Receptor Activator Activity AF-2 Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Biological_process	Ossification Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription From Mitochondrial Promoter Organelle Organization Mitochondrion Organization Actin Filament Organization Positive Regulation Of Alkaline Phosphatase Activity Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Reactive Oxygen Species Positive Regulation Of Phosphorylation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Glucocorticoid Response To CAMP Bone Trabecula Formation Positive Regulation Of Receptor Activity
Pathways		Generic Transcription Pathway	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Tanning ( 19340012)
Protein-Protein Interactions		3 interactors: PPARGC1B SKIL UBC	13 interactors: AKT1 ESR1 ESRRG HCFC1 HNF4A PPARA SRC THRB ZBTB9 ZFP64 ZNF200 ZNF212 ZNF513
Entrez ID		7752	133522
HPRD ID		04452	10594
Ensembl ID		ENSG00000010539	ENSG00000155846
Uniprot IDs		B3KP91 P98182	B7ZM40 Q86YN6
PDB IDs			3SP6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Response To Transforming Growth Factor Beta Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Cell Cycle Response To Organic Substance Transcription From Mitochondrial Promoter Viral Protein Processing Bone Trabecula Formation Protein Heterotrimerization Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Programmed Cell Death Response To Growth Factor Positive Regulation Of Bone Resorption Positive Regulation Of Cell Death Intracellular Estrogen Receptor Signaling Pathway Protein Homotrimerization Regulation Of Signaling Bone Trabecula Morphogenesis RNA Metabolic Process Response To Cytokine Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter	Cellular Response To Steroid Hormone Stimulus Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Intracellular Receptor Signaling Pathway Transcription, DNA-templated Cellular Response To Organic Cyclic Compound RNA Biosynthetic Process Gene Expression Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Hormone-mediated Signaling Pathway Cellular Response To Hormone Stimulus Positive Regulation Of Gene Expression RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Lipid Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Response To Steroid Hormone DNA-templated Transcription, Initiation Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Lipid Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Regulation Of Lipid Metabolic Process Cellular Metabolic Process Mammary Gland Epithelium Development Cellular Response To Organic Substance Regulation Of Glucose Metabolic Process Uterus Development Regulation Of Fatty Acid Beta-oxidation Intracellular Estrogen Receptor Signaling Pathway
Tagcloud ?		alignment arrays bait belongs cdna derivatives discrete drosophila encompassing evolutionarily finger g9a ghd gst hek293 hg9a homology immunoprecipitation k9 localize methyltransferases named nucleoplasm partner pull speckles subfamily tandem zinc	17beta abundantly biased coagulation constituted dimorphic dimorphism etc feminized hnf4a insensitive keto kt11 livers lxr metabolisms mycn oviparous retinol sage sexes spawning stat4 transcriptomes transcriptomic vitellogenin viviparous xenobiotic zebrafish
Tagcloud (Difference) ?		alignment arrays bait belongs cdna derivatives discrete drosophila encompassing evolutionarily finger g9a ghd gst hek293 hg9a homology immunoprecipitation k9 localize methyltransferases named nucleoplasm partner pull speckles subfamily tandem zinc	17beta abundantly biased coagulation constituted dimorphic dimorphism etc feminized hnf4a insensitive keto kt11 livers lxr metabolisms mycn oviparous retinol sage sexes spawning stat4 transcriptomes transcriptomic vitellogenin viviparous xenobiotic zebrafish
Tagcloud (Intersection) ?