ALOXE3

Description		arachidonate epidermal lipoxygenase 3
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Lyase Activity Isomerase Activity Metal Ion Binding Intramolecular Hydroxytransferase Activity Dioxygenase Activity Hydroperoxy Icosatetraenoate Isomerase Activity Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Sensory Perception Of Pain Arachidonate Metabolic Process Lipoxygenase Pathway Lipid Oxidation Peroxisome Proliferator Activated Receptor Signaling Pathway Linoleic Acid Metabolic Process Fat Cell Differentiation Ceramide Biosynthetic Process Hepoxilin Biosynthetic Process Establishment Of Skin Barrier
Pathways		Synthesis of 12-eicosatetraenoic acid derivatives
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS
Interacting Genes		2 interacting genes: YY1 ZNF76
Entrez ID		59344
HPRD ID		06231
Ensembl ID		ENSG00000179148
Uniprot IDs		A0AAQ5BHH1 Q9BYJ1
PDB IDs		6VB2
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding Regulation Of DNA Strand Elongation V(D)J Recombination Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of Interferon-beta Production DNA-binding Transcription Repressor Activity Four-way Junction DNA Binding Sequence-specific Double-stranded DNA Binding Immunoglobulin V(D)J Recombination Ino80 Complex Response To Prostaglandin F Positive Regulation Of Telomere Maintenance In Response To DNA Damage Response To UV-C DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Chromatin Silencing Complex PcG Protein Complex Camera-type Eye Morphogenesis Negative Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cardiac Muscle Tissue Growth Regulation Of Transcription By RNA Polymerase III Somatic Recombination Of Immunoglobulin Gene Segments RNA Localization Negative Regulation Of Organ Growth DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Striated Muscle Cell Differentiation Somatic Cell DNA Recombination Negative Regulation Of Muscle Hypertrophy Somatic Diversification Of Immunoglobulins Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Type I Interferon Production Negative Regulation Of Cardiac Muscle Hypertrophy SMAD Binding Cellular Response To Interleukin-1 Eye Morphogenesis Regulation Of Interferon-beta Production Regulation Of Heart Growth Positive Regulation Of Telomere Maintenance Sensory Organ Morphogenesis Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Response To Interleukin-1 Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Embryonic Development Cellular Response To UV
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