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CYP2J2 and ZBTB25
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
CYP2J2
ZBTB25
Gene Name
cytochrome P450, family 2, subfamily J, polypeptide 2
zinc finger and BTB domain containing 25
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Intracellular Membrane-bounded Organelle
Extracellular Vesicular Exosome
Nucleoplasm
Cytoplasm
Molecular Function
Iron Ion Binding
Arachidonic Acid Epoxygenase Activity
Steroid Hydroxylase Activity
Arachidonic Acid 14,15-epoxygenase Activity
Arachidonic Acid 11,12-epoxygenase Activity
Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen
Oxygen Binding
Heme Binding
Aromatase Activity
Linoleic Acid Epoxygenase Activity
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Metal Ion Binding
Biological Process
Icosanoid Metabolic Process
Xenobiotic Metabolic Process
Regulation Of Heart Contraction
Arachidonic Acid Metabolic Process
Epoxygenase P450 Pathway
Exogenous Drug Catabolic Process
Linoleic Acid Metabolic Process
Small Molecule Metabolic Process
Oxidation-reduction Process
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Gene Expression
Pathways
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
Metabolism of lipids and lipoproteins
Metabolic disorders of biological oxidation enzymes
Phase 1 - Functionalization of compounds
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
Arachidonic acid metabolism
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
Cytochrome P450 - arranged by substrate type
Biological oxidations
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
Defective FMO3 causes Trimethylaminuria (TMAU)
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
Defective CYP1B1 causes Glaucoma
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
Fatty acids
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
Xenobiotics
Defective MAOA causes Brunner syndrome (BRUNS)
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS
Protein-Protein Interactions
2 interactors:
TCEB1
ZBTB25
20 interactors:
APIP
COIL
CYP2J2
DDIT3
FCGR3A
HCLS1
KCTD1
KXD1
LZTS2
MAPK9
MDFI
PCBD1
PNMA5
SEPHS1
SORBS3
SSX3
TNIP1
TRAF2
TSSK3
ZBTB1
Entrez ID
1573
7597
HPRD ID
03159
01926
Ensembl ID
ENSG00000134716
Uniprot IDs
P51589
P24278
PDB IDs
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of Viral Transcription
Regulation Of DNA-templated Transcription, Elongation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Transcription Elongation From RNA Polymerase II Promoter
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
Regulation Of Phosphorylation
Regulation Of MAPK Cascade
Regulation Of Phosphorus Metabolic Process
Regulation Of Signal Transduction
Positive Regulation Of Phosphorylation
Regulation Of Signaling
Protein Homooligomerization
MRNA Transcription From RNA Polymerase II Promoter
Positive Regulation Of Immune System Process
MRNA Transcription
Toll-like Receptor Signaling Pathway
Protein Complex Assembly
Regulation Of Transcription, DNA-templated
Regulation Of Protein Homodimerization Activity
Positive Regulation Of Immune Response
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
Regulation Of Intracellular Signal Transduction
Regulation Of JNK Cascade
Protein Oligomerization
Regulation Of Immune System Process
Regulation Of Gene Expression
Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Innate Immune Response
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Immune Response-regulating Signaling Pathway
Regulation Of Immune Response
Regulation Of Protein Localization To Nucleus
Positive Regulation Of Protein Modification Process
Regulation Of Apoptotic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Determination Of Dorsal Identity
Positive Regulation Of Pro-T Cell Differentiation
Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade
Regulation Of Cell Death
Regulation Of Innate Immune Response
Regulation Of Binding
Positive Regulation Of Apoptotic Process
Tagcloud
?
25369t
287gln
2c
36755a
36785a
404del
55arg
816g
aneurysmal
asah
bonferroni
cnd
cyp2c8
cyp2c9
dci
dhet
dihydroxyeicosatetraenoic
eet
eets
eicosanoid
ephx2
epoxyeicosatrienoic
jcbfm
journal
mrs
passed
rankin
subarachnoid
Tagcloud (Difference)
?
25369t
287gln
2c
36755a
36785a
404del
55arg
816g
aneurysmal
asah
bonferroni
cnd
cyp2c8
cyp2c9
dci
dhet
dihydroxyeicosatetraenoic
eet
eets
eicosanoid
ephx2
epoxyeicosatrienoic
jcbfm
journal
mrs
passed
rankin
subarachnoid
Tagcloud (Intersection)
?