MPPED1 and PHAF1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MPPED1	PHAF1
Name		metallophosphoesterase domain containing 1	phagophore assembly factor 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	Phagophore Assembly Site Cytoplasm Trans-Golgi Network Dendrite Synaptic Vesicle Membrane
	Molecular Function	Molecular_function Protein Binding Hydrolase Activity	Protein Binding
	Biological Process	Biological_process	Golgi To Plasma Membrane Protein Transport
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Sleep (1/2-day periodicity) ( 33075057 )	No GWAS studies recorded
Novel Interactors		None recorded	3 novel interactors: CYB5B ESRP2 QSOX1
Interacting Genes		6 interacting genes: ANXA7 DISC1 PHAF1 SPP1 TK1 ZRANB1	10 interacting genes: APP ATXN3 CBFA2T2 CCDC102B KIF17 MPPED1 NPBWR2 PRR5L TOLLIP TSHZ2
Entrez ID		758	80262
HPRD ID		03663	17460
Ensembl ID		ENSG00000186732	ENSG00000125149
Uniprot IDs		O15442	Q9BSU1
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Integrin Binding Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Positive Regulation Of Estradiol Secretion Regulation Of Estradiol Secretion Regulation Of Axonogenesis DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Pyramidal Neuron Migration To Cerebral Cortex Positive Regulation Of Wnt Signaling Pathway Central Region Of Growth Cone Response To Ketone Chromaffin Granule Membrane Regulation Of Anatomical Structure Morphogenesis Androgen Catabolic Process Cellular Response To Testosterone Stimulus Response To 2,3,7,8-tetrachlorodibenzodioxine Thymidine Metabolic Process Thymidine Biosynthetic Process Radial Glia-guided Pyramidal Neuron Migration Cerebral Cortex Radial Glia-guided Migration Protein K33-linked Deubiquitination Protein K29-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Response To Macrophage Colony-stimulating Factor Deoxyribonucleoside Monophosphate Biosynthetic Process Wnt Signaling Pathway Response To Phorbol 13-acetate 12-myristate Positive Regulation Of Bone Resorption Negative Regulation Of Collateral Sprouting Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Pyrimidine Nucleoside Metabolic Process	None