CFAP410 and ATOX1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		CFAP410	ATOX1
Name		cilia and flagella associated protein 410	antioxidant 1 copper chaperone
Structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Photoreceptor Cell Cilium	Cytosol
	Molecular Function	Protein Binding	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding Metal Ion Binding ATPase Binding Cuprous Ion Binding
	Biological Process	DNA Damage Response Cytoskeleton Organization Smoothened Signaling Pathway Regulation Of Cell Shape Cell Projection Organization Cilium Assembly	Monoatomic Ion Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Response To Oxidative Stress Negative Regulation Of Apoptotic Process Copper Ion Export
Pathways		None	Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface
Drugs		None	Cisplatin Sucrose Benzamidine
GWAS		No GWAS studies recorded	Creatinine levels ( 29403010 ) Glomerular filtration rate ( 29403010 ) Red cell distribution width ( 32888494 ) Systolic blood pressure change trajectory ( 27980656 )
Novel Interactors		2 novel interactors: COL6A1 DOP1B	None recorded
Interacting Genes		4 interacting genes: ATOX1 FBXO3 GMCL1 SPG21	9 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1 TRAF4
Entrez ID		755	475
HPRD ID		04427	03779
Ensembl ID		ENSG00000160226	ENSG00000177556
Uniprot IDs		O43822	O00244
PDB IDs		8AXR	1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L 7DC1 7ZC3
GO Terms Enriched among Interactors		None	Copper Ion Transport P-type Divalent Copper Transporter Activity P-type Monovalent Copper Transporter Activity Copper-dependent Protein Binding Copper Ion Export Copper Ion Import Copper Ion Transmembrane Transporter Activity Copper Ion Transmembrane Transport ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Copper Ion Binding Skin Development Collagen Fibril Organization Steroid Hormone Receptor Complex Assembly Geranylgeranyl Diphosphate Biosynthetic Process Prenyl Diphosphate Synthase Activity Geranylgeranyl Diphosphate Synthase Activity Geranyl Diphosphate Biosynthetic Process (2E,6E)-farnesyl Diphosphate Synthase Activity Dimethylallyltranstransferase Activity Cartilage Development Trans-Golgi Network Membrane Superoxide Dismutase Copper Chaperone Activity Geranyl Diphosphate Metabolic Process P-type Ion Transporter Activity Epinephrine Metabolic Process Tendon Development Cartilage Homeostasis Male Sex Differentiation Farnesyl Diphosphate Biosynthetic Process Negative Regulation Of Catecholamine Metabolic Process Sequestering Of Calcium Ion Late Endosome Metal Ion Transport Farnesyl Diphosphate Metabolic Process Pyramidal Neuron Development Viral Translational Frameshifting