ZFY and L3MBTL2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid)

		ZFY	L3MBTL2
Description		zinc finger protein Y-linked	L3MBTL histone methyl-lysine binding protein 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding Histone H4K20me2 Reader Activity Histone H4K20me1 Reader Activity Promoter-specific Chromatin Binding
	Biological Process	Ovarian Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Germ Cell Development Spermatogenesis Fertilization Post-embryonic Development Multicellular Organism Growth Positive Regulation Of Transcription By RNA Polymerase II Oocyte Development Homeostasis Of Number Of Cells Parental Behavior	Chromatin Organization Regulation Of DNA-templated Transcription Ectoderm Development Negative Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Stem Cell Differentiation Stem Cell Proliferation
Pathways			SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6
Drugs		3-Cyclohexyl-L-alanine Picolinic acid
Diseases
GWAS			Adventurousness ( 30643258) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety ( 33859377) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 26192919) Depression ( 29700475) General risk tolerance (MTAG) ( 30643258) Inflammatory bowel disease ( 26192919) Lamb consumption ( 32066663) Major depressive disorder ( 27479909) Neuroticism ( 27918536 29255261) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		4 interacting genes: DMRT3 KAT14 L3MBTL2 ZBTB9	49 interacting genes: AMOTL2 BEND7 BIVM CARD9 CCDC106 CCDC33 CEP76 DRC4 EFHC2 EIF4ENIF1 FAM217B GKAP1 GOLGA2 GPRASP3 H3C1 H4C1 HSF2BP LNX2 MEAF6 MEOX1 MPP3 NRF1 PAICS PHF10 PIAS1 PICK1 POU6F2 PRKAR1B RBAK REL SSUH2 STAC3 STAM2 TAX1BP1 TBC1D9B TEKT1 THAP1 THAP11 TLE5 TNNI1 TRIM42 TRIM50 TSPYL1 ZBTB26 ZBTB48 ZFP64 ZFY ZNF467 ZNF829
Entrez ID		7544	83746
HPRD ID		02466	13954
Ensembl ID		ENSG00000067646	ENSG00000100395
Uniprot IDs		P08048	A0A0S2Z5X6 Q969R5
PDB IDs		1KLR 1KLS 1XRZ 5ZNF 7ZNF	2W0T 3CEY 3F70
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process LIM Domain Binding Male Sex Differentiation Ventral Spinal Cord Interneuron Specification Histone H4K20me1 Reader Activity Histone H4K20me2 Reader Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Odontogenesis Of Dentin-containing Tooth ATAC Complex Ectoderm Development Regulation Of Odontogenesis Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity Regulation Of Primary Metabolic Process Regulation Of Gene Expression Neuron Fate Specification Sex Differentiation Transmission Of Nerve Impulse Adult Walking Behavior Walking Behavior Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Metabolic Process Regulation Of Embryonic Development Nucleus Adult Locomotory Behavior Regulation Of Animal Organ Morphogenesis Cell Fate Specification RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Promoter-specific Chromatin Binding Stem Cell Proliferation	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
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