VIPR1 and RAMP2

Number of citations of the paper that reports this interaction (PMID 12446722)
51

Data Source:
HPRD (in vitro)

		VIPR1	RAMP2
Gene Name		vasoactive intestinal peptide receptor 1	receptor (G protein-coupled) activity modifying protein 2
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Cell Surface Receptor Complex
	Molecular Function	Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding	Protein Binding Protein Transporter Activity Coreceptor Activity
	Biological Process	Muscle Contraction Immune Response G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Digestion Positive Regulation Of Cell Proliferation	Angiogenesis Vasculogenesis Response To Hypoxia Sprouting Angiogenesis CAMP Biosynthetic Process Calcium Ion Transport Intracellular Protein Transport G-protein Coupled Receptor Signaling Pathway Heart Development Female Pregnancy Regulation Of Blood Pressure Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Development Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Pramlintide
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ADCYAP1 CALM1 GNAI1 GNAQ GNAS GPRASP1 PFN1 PTMA RAMP1 RAMP2 RAMP3 SCT TINF2 VIP WASL	5 interactors: CALCA CALCRL IAPP SLC31A2 VIPR1
Entrez ID		7433	10266
HPRD ID		01890	05516
Ensembl ID		ENSG00000114812	ENSG00000131477
Uniprot IDs		B4DNY6 P32241	K7EMD3 O60895
PDB IDs		1OF2 1OGT 3B3I	2XVT 3AQE 3AQF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Lyase Activity G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Platelet Activation Receptor Metabolic Process Cellular Localization Activation Of Adenylate Cyclase Activity Establishment Of Localization In Cell Secretion Transport Receptor Internalization Cell Surface Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Protein Localization Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Membrane Organization Vesicle-mediated Transport Response To Hormone Regulation Of Phosphorus Metabolic Process Regulation Of Protein Glycosylation Positive Regulation Of Cellular Biosynthetic Process Wound Healing Negative Regulation Of Ion Transport Cell Activation Response To Wounding Protein Localization CAMP Biosynthetic Process Negative Regulation Of Potassium Ion Transport Regulation Of Signal Transduction Protein Localization To Plasma Membrane Response To Lipid Regulation Of Glycoprotein Biosynthetic Process Nitric Oxide Metabolic Process Response To Organic Cyclic Compound	Negative Regulation Of Bone Resorption G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Regulation Of Bone Resorption Receptor Internalization Regulation Of Bone Remodeling Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Regulation Of Tissue Remodeling Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Feeding Behavior Regulation Of CAMP Metabolic Process Regulation Of Copper Ion Transmembrane Transport Cellular Response To Sucrose Stimulus Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Muscle Contraction Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Regulation Of Inflammatory Response Negative Regulation Of Calcium Ion Transport Into Cytosol Receptor-mediated Endocytosis Positive Regulation Of Macrophage Differentiation Copper Ion Transmembrane Transport G-protein Coupled Receptor Internalization Cellular Metal Ion Homeostasis Negative Regulation Of Neurological System Process Monocyte Chemotaxis Negative Regulation Of Smooth Muscle Contraction Cellular Cation Homeostasis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cellular Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Sucrose Endothelial Cell Proliferation Metal Ion Homeostasis Cellular Copper Ion Homeostasis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Muscle Contraction CAMP Biosynthetic Process Copper Ion Homeostasis Cellular Chemical Homeostasis
Tagcloud ?		10k ac calca canonical cervix cervixes checkpoint differentially g2 genomics globally igfbp2 immunological krt17 networks oligomicroarray pheochromocytoma ppargamma rnas scc separated signature signatures splenomegaly transcriptomic transcripts urgent uterine utilized	abundantly accessory adrenomedullin bioactivities calcitonin ccaat clr evokes exerting glomeruli glut2 illustrating lethality littermates pathophysiological perk ramps reproduce rptecs streptozotocin stz subisoforms takes tubular tubule tubules tun tunicamycin
Tagcloud (Difference) ?		10k ac calca canonical cervix cervixes checkpoint differentially g2 genomics globally igfbp2 immunological krt17 networks oligomicroarray pheochromocytoma ppargamma rnas scc separated signature signatures splenomegaly transcriptomic transcripts urgent uterine utilized	abundantly accessory adrenomedullin bioactivities calcitonin ccaat clr evokes exerting glomeruli glut2 illustrating lethality littermates pathophysiological perk ramps reproduce rptecs streptozotocin stz subisoforms takes tubular tubule tubules tun tunicamycin
Tagcloud (Intersection) ?