UNG and DAO

		UNG	DAO
Description		uracil DNA glycosylase	D-amino acid oxidase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Extracellular Region Extracellular Space Cytoplasm Mitochondrial Outer Membrane Peroxisome Peroxisomal Matrix Cytosol Cell Projection Synapse Presynaptic Active Zone
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Ribosomal Small Subunit Binding	D-amino-acid Oxidase Activity Protein Binding D-amino-acid Dehydrogenase Activity Oxidoreductase Activity Identical Protein Binding Glycine Oxidase Activity FAD Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal	L-leucine Metabolic Process L-proline Catabolic Process Digestion D-amino Acid Catabolic Process D-serine Catabolic Process Dopamine Biosynthetic Process D-amino Acid Metabolic Process Killing By Host Of Symbiont Cells D-alanine Catabolic Process D-serine Metabolic Process Neutrophil-mediated Killing Of Gram-negative Bacterium L-amino Acid Catabolic Process Proteinogenic Amino Acid Catabolic Process
Pathways			Glyoxylate metabolism and glycine degradation Peroxisomal protein import Peroxisomal protein import
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid	3,4-Dihydro-2h-Pyrrolium-5-Carboxylate Imino-Tryptophan Flavin adenine dinucleotide D-Tryptophan Flavin-adenine dinucleotide-N5-isobutyl ketone Benzoic acid Anthranilic acid (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494) Nicotine dependence and major depression (severity of comorbidity) ( 30287806)
Interacting Genes		6 interacting genes: APP CAPN11 CEBPA PCNA RPA2 SEZ6L2	5 interacting genes: AOC1 DAOA EP300 PEX5 PRKAB2
Entrez ID		7374	1610
HPRD ID		01881	15917
Ensembl ID		ENSG00000076248	ENSG00000110887
Uniprot IDs		E5KTA5 E5KTA6 P13051	A0A024RBI1 A0A0S2Z3J4 P14920
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7 6VBA 7V7C	2DU8 2E48 2E49 2E4A 2E82 3CUK 3G3E 3W4I 3W4J 3W4K 3ZNN 3ZNO 3ZNP 3ZNQ 4QFC 4QFD 5ZJ9 5ZJA 6KBP 7U9S 7U9U 8HY5
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Structure Or Activity Amyloid-beta Complex Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Chemical Homeostasis Homeostatic Process Enzyme Binding Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process Memory P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Longitudinal Sarcoplasmic Reticulum RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Regulation Of DNA Damage Checkpoint FAD Binding Presynaptic Active Zone D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide PCNA Complex Replisome Mismatch Repair Response To Ketone Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Cellular Response To Stress Positive Regulation Of Protein Import Calcium Ion-transporting ATPase Complex Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Neuron Cellular Homeostasis Cellular Response To Xenobiotic Stimulus Animal Organ Regeneration Response To Vitamin B2 C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity	Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Peptidyl-lysine Propionylation Carboxylic Acid Metabolic Process Swimming Histone Lactyltransferase (CoA-dependent) Activity Organic Acid Metabolic Process Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Damaged DNA Binding Small Molecule Metabolic Process Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Nucleotide Catabolic Process Peptide Lactyltransferase (CoA-dependent) Activity Peroxisome Targeting Sequence Binding Peroxisome Monocarboxylic Acid Metabolic Process Negative Regulation Of Protein Oligomerization Nucleoside Phosphate Catabolic Process Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Uracil DNA N-glycosylase Activity D-amino Acid Metabolic Process
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