UNG and CAPN11

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		UNG	CAPN11
Description		uracil DNA glycosylase	calpain 11
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Acrosomal Vesicle Cytoplasm Cytoplasmic Vesicle
	Molecular Function	Damaged DNA Binding Uracil DNA N-glycosylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Ribosomal Small Subunit Binding	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Single Strand Break Repair DNA Repair Base-excision Repair DNA Damage Response Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Negative Regulation Of Apoptotic Process Depyrimidination Isotype Switching Base-excision Repair, AP Site Formation Via Deaminated Base Removal	Proteolysis
Pathways			Degradation of the extracellular matrix
Drugs		4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
Diseases		Hyper IgM syndromes, autosomal recessive type, including the following three diseases: Activation-induced cytidine deaminase (AICD) defect; Uracil nucleotide glycoside glycosylase (UNG) defect; Immunodeficiency with hyper-IgM type 3
GWAS		Feeling miserable ( 29500382) Feeling worry ( 29500382) Neurociticism ( 29500382) Worry too long after an embarrassing experience ( 29500382)	Red cell distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: APP CAPN11 CEBPA PCNA RPA2 SEZ6L2	4 interacting genes: ANAPC11 PRKAR1A UNG XRCC6
Entrez ID		7374	11131
HPRD ID		01881	05315
Ensembl ID		ENSG00000076248	ENSG00000137225
Uniprot IDs		E5KTA5 E5KTA6 P13051	Q9UMQ6
PDB IDs		1AKZ 1DPU 1EMH 1EMJ 1Q3F 1SSP 1UGH 1YUO 2HXM 2OXM 2OYT 2SSP 3FCF 3FCI 3FCK 3FCL 3TKB 4SKN 5AYR 5JK7 6VBA 7V7C
Enriched GO Terms of Interacting Partners?		Regulation Of Synapse Structure Or Activity Amyloid-beta Complex Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Chemical Homeostasis Homeostatic Process Enzyme Binding Regulation Of Response To Calcium Ion Developmental Maturation Amylin Binding Inorganic Ion Homeostasis Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process Memory P-type Calcium Transporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Longitudinal Sarcoplasmic Reticulum RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Dexamethasone Regulation Of DNA Damage Checkpoint FAD Binding Presynaptic Active Zone D-serine Catabolic Process Glycine Oxidase Activity D-amino-acid Dehydrogenase Activity D-alanine Catabolic Process G Protein-coupled UDP Receptor Activity Cellular Response To Pyrimidine Ribonucleotide PCNA Complex Replisome Mismatch Repair Response To Ketone Acetylcholine Receptor Activator Activity Lipoprotein Particle Regulation Of Cellular Response To Stress Positive Regulation Of Protein Import Calcium Ion-transporting ATPase Complex Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Neuron Cellular Homeostasis Cellular Response To Xenobiotic Stimulus Animal Organ Regeneration Response To Vitamin B2 C/EBP Complex Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity D-serine Metabolic Process D-amino Acid Catabolic Process D-amino-acid Oxidase Activity	Damaged DNA Binding Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Hyperosmotic Salinity Response DNA End Binding Cellular Hyperosmotic Salinity Response Nuclear Telomere Cap Complex DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Cellular Response To Salt Stress DNA-dependent Protein Kinase Complex Ku70:Ku80 Complex Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex DNA Recombination CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Cellular Response To Glucagon Stimulus Base-excision Repair, AP Site Formation Via Deaminated Base Removal Single Strand Break Repair Uracil DNA N-glycosylase Activity Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Depyrimidination Cellular Hyperosmotic Response Telomeric DNA Binding Hyperosmotic Response Response To X-ray DNA Repair Regulation Of Lymphocyte Activation Cellular Response To Gamma Radiation Response To Salt Stress Cardiac Muscle Cell Proliferation CAMP Binding Protein Kinase A Catalytic Subunit Binding Response To Glucagon Negative Regulation Of Activated T Cell Proliferation Sperm Head-tail Coupling Apparatus Negative Regulation Of CAMP/PKA Signal Transduction Somatic Hypermutation Of Immunoglobulin Genes Deoxyribose Phosphate Catabolic Process Isotype Switching Base-excision Repair, AP Site Formation Ribosomal Small Subunit Binding Somatic Diversification Of Immunoglobulins Involved In Immune Response Somatic Diversification Of Immune Receptors Via Somatic Mutation Deoxyribonucleotide Catabolic Process Pyrimidine Deoxyribonucleotide Catabolic Process DNA Modification
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