UGT2B7 and GABRA3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		UGT2B7	GABRA3
Gene Name		UDP glucuronosyltransferase 2 family, polypeptide B7	gamma-aminobutyric acid (GABA) A receptor, alpha 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane
	Molecular Function	Retinoic Acid Binding Glucuronosyltransferase Activity	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity
	Biological Process	Lipid Metabolic Process Androgen Metabolic Process Flavonoid Biosynthetic Process Cellular Response To Hormone Stimulus Cellular Glucuronidation Flavonoid Glucuronidation	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses
Drugs			Lorazepam Ethchlorvynol Temazepam Butabarbital Butalbital Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Secobarbital Zolpidem Metharbital Chlordiazepoxide Adinazolam Thiopental Clorazepate Midazolam Flurazepam Primidone Halazepam Diazepam Oxazepam Methylphenobarbital Triazolam Clonazepam Phenobarbital Zopiclone Estazolam Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Flunitrazepam Bromazepam Clotiazepam Fludiazepam Prazepam Quazepam Cinolazepam Nitrazepam
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		2 interactors: CYP3A4 GABRA3	3 interactors: SDCBP2 UBQLN1 UGT2B7
Entrez ID		7364	2556
HPRD ID		02508	02375
Ensembl ID		ENSG00000171234	ENSG00000011677
Uniprot IDs		P16662	P34903
PDB IDs		2O6L
Enriched GO Terms of Interacting Partners?		Alkaloid Catabolic Process Monoterpenoid Metabolic Process Calcitriol Biosynthetic Process From Calciol Alkaloid Metabolic Process Oxidative Demethylation Vitamin D Metabolic Process Exogenous Drug Catabolic Process Drug Catabolic Process Steroid Catabolic Process Gamma-aminobutyric Acid Signaling Pathway Drug Metabolic Process Androgen Metabolic Process Demethylation Vitamin Metabolic Process Chloride Transmembrane Transport Steroid Biosynthetic Process Isoprenoid Metabolic Process Chloride Transport Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Hormone Metabolic Process Lipid Catabolic Process Steroid Metabolic Process Inorganic Anion Transport Regulation Of Hormone Levels	Flavonoid Biosynthetic Process Flavonoid Glucuronidation Cellular Glucuronidation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Flavonoid Metabolic Process Androgen Metabolic Process Regulation Of Cellular Response To Oxidative Stress
Tagcloud ?		802c 802cc 802ct 802tt artekin artemether artemisinin artesunate auc0 auto cmax declining dha dihydroartemisinin glu glucuronidated hao i399c i399cc i399ct i399tt metabolite piperaquine polymorphic pq qing recover su ugt1a9
Tagcloud (Difference) ?		802c 802cc 802ct 802tt artekin artemether artemisinin artesunate auc0 auto cmax declining dha dihydroartemisinin glu glucuronidated hao i399c i399cc i399ct i399tt metabolite piperaquine polymorphic pq qing recover su ugt1a9
Tagcloud (Intersection) ?