GABRA3 and UGT2B7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GABRA3	UGT2B7
Gene Name		gamma-aminobutyric acid (GABA) A receptor, alpha 3	UDP glucuronosyltransferase 2 family, polypeptide B7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Postsynaptic Membrane	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	GABA-A Receptor Activity Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Benzodiazepine Receptor Activity	Retinoic Acid Binding Glucuronosyltransferase Activity
	Biological Process	Transport Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Ion Transmembrane Transport Transmembrane Transport Chloride Transmembrane Transport	Lipid Metabolic Process Androgen Metabolic Process Flavonoid Biosynthetic Process Cellular Response To Hormone Stimulus Cellular Glucuronidation Flavonoid Glucuronidation
Pathways		GABA receptor activation Ion channel transport GABA A receptor activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ligand-gated ion channel transport Orphan transporters Transmission across Chemical Synapses	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Lorazepam Ethchlorvynol Temazepam Butabarbital Butalbital Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Secobarbital Zolpidem Metharbital Chlordiazepoxide Adinazolam Thiopental Clorazepate Midazolam Flurazepam Primidone Halazepam Diazepam Oxazepam Methylphenobarbital Triazolam Clonazepam Phenobarbital Zopiclone Estazolam Amobarbital Aprobarbital Butethal Heptabarbital Hexobarbital Barbital Barbituric acid derivative Flunitrazepam Bromazepam Clotiazepam Fludiazepam Prazepam Quazepam Cinolazepam Nitrazepam
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: SDCBP2 UBQLN1 UGT2B7	2 interactors: CYP3A4 GABRA3
Entrez ID		2556	7364
HPRD ID		02375	02508
Ensembl ID		ENSG00000011677	ENSG00000171234
Uniprot IDs		P34903	P16662
PDB IDs			2O6L
Enriched GO Terms of Interacting Partners?		Flavonoid Biosynthetic Process Flavonoid Glucuronidation Cellular Glucuronidation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Flavonoid Metabolic Process Androgen Metabolic Process Regulation Of Cellular Response To Oxidative Stress	Alkaloid Catabolic Process Monoterpenoid Metabolic Process Calcitriol Biosynthetic Process From Calciol Alkaloid Metabolic Process Oxidative Demethylation Vitamin D Metabolic Process Exogenous Drug Catabolic Process Drug Catabolic Process Steroid Catabolic Process Gamma-aminobutyric Acid Signaling Pathway Drug Metabolic Process Androgen Metabolic Process Demethylation Vitamin Metabolic Process Chloride Transmembrane Transport Steroid Biosynthetic Process Isoprenoid Metabolic Process Chloride Transport Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Hormone Metabolic Process Lipid Catabolic Process Steroid Metabolic Process Inorganic Anion Transport Regulation Of Hormone Levels
Tagcloud ?			802c 802cc 802ct 802tt artekin artemether artemisinin artesunate auc0 auto cmax declining dha dihydroartemisinin glu glucuronidated hao i399c i399cc i399ct i399tt metabolite piperaquine polymorphic pq qing recover su ugt1a9
Tagcloud (Difference) ?			802c 802cc 802ct 802tt artekin artemether artemisinin artesunate auc0 auto cmax declining dha dihydroartemisinin glu glucuronidated hao i399c i399cc i399ct i399tt metabolite piperaquine polymorphic pq qing recover su ugt1a9
Tagcloud (Intersection) ?