UGT2B7

Gene Name		UDP glucuronosyltransferase 2 family, polypeptide B7
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Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Retinoic Acid Binding Glucuronosyltransferase Activity
	Biological Process	Lipid Metabolic Process Androgen Metabolic Process Flavonoid Biosynthetic Process Cellular Response To Hormone Stimulus Cellular Glucuronidation Flavonoid Glucuronidation
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Glucuronidation Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		2 interactors: CYP3A4 GABRA3
Entrez ID		7364
HPRD ID		02508
Ensembl ID		ENSG00000171234
Uniprot IDs		P16662
PDB IDs		2O6L
Enriched GO Terms of Interacting Partners?		Alkaloid Catabolic Process Monoterpenoid Metabolic Process Calcitriol Biosynthetic Process From Calciol Alkaloid Metabolic Process Oxidative Demethylation Vitamin D Metabolic Process Exogenous Drug Catabolic Process Drug Catabolic Process Steroid Catabolic Process Gamma-aminobutyric Acid Signaling Pathway Drug Metabolic Process Androgen Metabolic Process Demethylation Vitamin Metabolic Process Chloride Transmembrane Transport Steroid Biosynthetic Process Isoprenoid Metabolic Process Chloride Transport Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Response To Xenobiotic Stimulus Hormone Metabolic Process Lipid Catabolic Process Steroid Metabolic Process Inorganic Anion Transport Regulation Of Hormone Levels
Tagcloud ?		802c 802cc 802ct 802tt artekin artemether artemisinin artesunate auc0 auto cmax declining dha dihydroartemisinin glu glucuronidated hao i399c i399cc i399ct i399tt metabolite piperaquine polymorphic pq qing recover su ugt1a9