PGPEP1

Name	pyroglutamyl-peptidase I
Structure	No pdb structure
Interactors	4 interactors: AQP1 NTAQ1 UBE2E2 UBE2E3
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Pyroglutamyl-peptidase Activity
	Biological Process	Proteolysis Protein Catabolic Process
GWAS	Adult body size ( 32376654 ) BMI (adjusted for smoking behaviour) ( 28443625 ) Body mass index ( 25673413 26961502 28892062 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Chronotype ( 30696823 ) Coronary artery disease ( 29212778 ) Gastroesophageal reflux disease ( 34187846 31527586 ) Growth differentiation factor-15 levels ( 22997280 29628937 ) Growth differentiation factor-15 levels (conditioned on rs888663) ( 29628937 ) Hand grip strength ( 29691431 ) Medication use (beta blocking agents) ( 31015401 ) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965 ) Periodontitis (Mean PAL) ( 24024966 ) Systemic lupus erythematosus ( 26606652 )
Entrez ID	54858
HPRD ID	07141
Ensembl ID	ENSG00000130517
Uniprot IDs	Q9NXJ5 S4R2Y9 U3KQ24
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Protein K11-linked Ubiquitination Ubiquitin Conjugating Enzyme Activity Metanephric Descending Thin Limb Development Metanephric Proximal Straight Tubule Development Nitric Oxide Transmembrane Transporter Activity Metanephric Proximal Convoluted Tubule Segment 2 Development Protein Monoubiquitination Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Protein-N-terminal Glutamine Amidohydrolase Activity Metanephric Glomerulus Vasculature Development Glycerol Transmembrane Transporter Activity Corticotropin Secretion Protein-N-terminal Asparagine Amidohydrolase Activity Positive Regulation Of Saliva Secretion Cellular Response To Mercury Ion Hydrogen Peroxide Channel Activity Potassium Ion Transmembrane Transporter Activity Nitric Oxide Transport Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cerebrospinal Fluid Secretion Renal Water Absorption Carbon Dioxide Transmembrane Transporter Activity Glomerulus Vasculature Development Water Transmembrane Transporter Activity Transepithelial Water Transport Hydrogen Peroxide Transmembrane Transport Intracellularly CGMP-activated Cation Channel Activity Carbon Dioxide Transmembrane Transport Lipid Digestion Pancreatic Juice Secretion ISG15-protein Conjugation ISG15 Transferase Activity Ubiquitin-protein Transferase Activity Ankyrin-1 Complex Glycerol Transmembrane Transport Intracellular Water Homeostasis Protein Polyubiquitination Renal Water Transport Regulation Of Saliva Secretion Ammonium Channel Activity Polyol Transmembrane Transport Response To Mercury Ion Ammonium Transmembrane Transport Cellular Response To Salt Stress Positive Regulation Of Digestive System Process Epithelial Fluid Transport Metanephric Nephron Tubule Development Lateral Ventricle Development Water Channel Activity