FAM72A and MPPED2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FAM72A	MPPED2
Description		family with sequence similarity 72 member A	metallophosphoesterase domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Protein Binding Phosphoric Diester Hydrolase Activity AMP Binding Hydrolase Activity GMP Binding Manganese Ion Binding Metal Ion Binding
	Biological Process
Pathways
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Asthma ( 27611488) Automobile speeding propensity ( 30643258) Blood urea nitrogen levels ( 29403010) Chronic kidney disease ( 22479191 26831199) Chronotype ( 30696823) Creatinine levels ( 29403010) Dental caries ( 21940522) Estimated glomerular filtration rate ( 31015462 30604766) Falling risk ( 32999390) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 27479909) Medication use (diuretics) ( 31015401) Migraine ( 27322543) Morning person ( 30696823) Pit-and-Fissure caries ( 24556642) PR interval ( 32439900) Refractive error ( 32231278) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum uric acid levels ( 30993211 29403010) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30578418) Triglyceride levels ( 32203549) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: MPPED2 NTAQ1	14 interacting genes: BEX4 CAGE1 FAM72A HOOK2 IKZF1 MBD3L1 NOTCH3 NUP93 POMP RIBC1 RUNX1 RXRG TRIP13 VAC14
Entrez ID		729533	744
HPRD ID			02947
Ensembl ID		ENSG00000196550	ENSG00000066382
Uniprot IDs		Q5TYM5 Q5TYM6 U3KPW2	Q15777
PDB IDs
Enriched GO Terms of Interacting Partners?		GMP Binding Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity AMP Binding Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Phosphoric Diester Hydrolase Activity Manganese Ion Binding Hydrolase Activity
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