TSPY3 and CDC7

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TSPY3	CDC7
Name		testis specific protein Y-linked 3	cell division cycle 7
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle
	Molecular Function	Chromatin Binding Histone Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Nucleosome Assembly Spermatogenesis Gonadal Mesoderm Development Cell Differentiation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Division
Pathways		None	Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
GWAS		No GWAS studies recorded	Eosinophil percentage of white cells ( 27863252 ) Gestational age at birth (maternal effect) ( 28877031 ) Glaucoma (primary open-angle) ( 33627673 25861811 ) Lung function (FEV1/FVC) ( 28166213 ) Lung function (FVC) ( 26635082 ) Optic disc area ( 21307088 31798171 28073927 25631615 ) Optic disc parameters ( 20548946 ) Optic disc size ( 31809533 ) Optic nerve measurement (cup-to-disc ratio) ( 28061514 ) Plateletcrit ( 32888494 ) PR interval ( 32439900 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Vertical cup-disc ratio ( 28073927 25241763 31798171 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )
Interacting Genes		2 interacting genes: CDC7 DPY30	52 interacting genes: APP BANP CALCOCO2 CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 DTD1 FXR1 GMEB2 GOLGA2 GOLGA6A GPT GRHPR HMBOX1 HOMEZ IKZF1 IKZF3 IKZF4 LZTS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MEOX2 MTUS2 NDUFB2 ORC1 ORC5 ORC6 PGK1 SERTAD2 STAM2 TMBIM6 TOB1 TRIM27 TRIM37 TSNAXIP1 TSPY10 TSPY3 ZBTB10 ZBTB26 ZBTB8B
Entrez ID		728137	8317
HPRD ID		19080	10345
Ensembl ID		ENSG00000228927	ENSG00000097046
Uniprot IDs		F2Z2I4 P0CV98 P0CW01 Q01534	A0A384MTU6 B2R6V2 O00311
PDB IDs		Not available	4F99 4F9A 4F9B 4F9C 5UWQ 5UWR 6YA6 6YA7 6YA8
GO Terms Enriched among Interactors		Double-strand Break Repair Via Break-induced Replication Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of DNA-templated DNA Replication Set1C/COMPASS Complex MLL1/2 Complex MLL3/4 Complex Positive Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Methyltransferase Complex MLL1 Complex Positive Regulation Of DNA Replication Positive Regulation Of Gene Expression, Epigenetic Transcription Initiation-coupled Chromatin Remodeling	DNA Replication Initiation DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region DNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Replication Origin Binding Single-stranded DNA Helicase Activity Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Single-stranded DNA Binding Mitotic DNA Replication Initiation Regulation Of Metabolic Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Repair Double-strand Break Repair Via Homologous Recombination DNA Damage Response Recombinational Repair DNA Helicase Activity Positive Regulation Of DNA Replication Dbf4-dependent Protein Kinase Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Negative Regulation Of RNA Metabolic Process Chromatin Regulation Of Mitotic Cell Cycle DNA Strand Elongation Mesoderm Development Chromatin Organization Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity