AZU1

Name	azurocidin 1
Structure
Interactors	2 interactors: CLEC4G TTK
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Membrane Azurophil Granule Membrane Azurophil Granule Lumen Azurophil Granule Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Toxic Substance Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Microglial Cell Activation Proteolysis Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Glial Cell Migration Antimicrobial Humoral Response Positive Regulation Of Fractalkine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Monocyte Extravasation Monocyte Activation Defense Response To Bacterium Negative Regulation Of Apoptotic Process Regulation Of Vascular Permeability Cellular Extravasation Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Induction Of Positive Chemotaxis Protein Maturation Defense Response To Virus Cell Chemotaxis Neutrophil-mediated Killing Of Bacterium
Pathways	Neutrophil degranulation
GWAS	Blood protein levels ( 30072576 )
Entrez ID	566
HPRD ID	01221
Ensembl ID	ENSG00000172232
Uniprot IDs	P20160
PDB IDs	1A7S 1AE5 1FY1 1FY3
GO Terms Enriched among Interactors ?	Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Meiotic Spindle Midzone Virus Coreceptor Activity Repair Of Mitotic Kinetochore Microtubule Attachment Defect Meiotic Spindle Checkpoint Signaling Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle Glycosylated Region Protein Binding Female Meiosis Chromosome Segregation Kinetochore Binding Negative Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Immature T Cell Proliferation Immature T Cell Proliferation In Thymus Negative Regulation Of Meiotic Cell Cycle Phase Transition Fructose Binding Meiotic Cell Cycle Checkpoint Signaling Carbohydrate Derivative Binding Negative Regulation Of T Cell Differentiation In Thymus Protein Localization To Kinetochore Polysaccharide Binding Regulation Of Immature T Cell Proliferation In Thymus Meiotic Chromosome Segregation Alpha-beta T Cell Proliferation Negative Regulation Of Alpha-beta T Cell Proliferation Negative Regulation Of Meiotic Cell Cycle D-mannose Binding Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Viral Life Cycle Protein Serine/threonine/tyrosine Kinase Activity Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition T Cell Mediated Immunity Negative Regulation Of T Cell Mediated Immunity Negative Regulation Of Mitotic Nuclear Division Protein Localization To Chromosome, Centromeric Region Pattern Recognition Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Protein Localization To Cytoskeleton Negative Regulation Of Alpha-beta T Cell Activation Nuclear Chromosome Segregation Negative Regulation Of T Cell Differentiation Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Lymphocyte Differentiation Positive Regulation Of Viral Process Regulation Of SMAD Protein Signal Transduction Regulation Of Meiotic Cell Cycle Negative Regulation Of Reproductive Process Regulation Of Chromosome Separation Negative Regulation Of T Cell Proliferation T Cell Proliferation Negative Regulation Of Adaptive Immune Response