TTC4 and RXFP4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		TTC4	RXFP4
Description		tetratricopeptide repeat domain 4	relaxin family peptide/INSL5 receptor 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Plasma Membrane Membrane
	Molecular Function	Protein Binding Hsp70 Protein Binding Hsp90 Protein Binding	G Protein-coupled Receptor Activity Galanin Receptor Activity Protein Binding
	Biological Process	Immune System Process Protein Folding Innate Immune Response Defense Response To Virus	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Positive Regulation Of Feeding Behavior
Pathways			G alpha (i) signalling events Relaxin receptors
Drugs
Diseases
GWAS			A body shape index ( 34021172) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: OGT RXFP4 SNAPC3	10 interacting genes: ACTR10 GAPDH GJA8 KNG1 MAGED1 QDPR RLN3 TSPAN3 TTC4 TTI1
Entrez ID		7268	339403
HPRD ID		08417	16421
Ensembl ID		ENSG00000243725	ENSG00000173080
Uniprot IDs		O95801	Q8TDU9
PDB IDs		6HFO	7YJ4 7YK6 7YK7
Enriched GO Terms of Interacting Partners?		Bent DNA Binding SnRNA-activating Protein Complex RNA Polymerase III Type 3 Promoter Sequence-specific DNA Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Galanin Receptor Activity SnRNA Transcription By RNA Polymerase III Regulation Of Transcription By Glucose SnRNA Transcription By RNA Polymerase II NSL Complex Positive Regulation Of Feeding Behavior RNA Polymerase III General Transcription Initiation Factor Activity SnRNA Transcription Core Promoter Sequence-specific DNA Binding Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Acetylglucosaminyltransferase Activity Sin3-type Complex Histone Acetyltransferase Complex Negative Regulation Of Stem Cell Population Maintenance Regulation Of Feeding Behavior
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