ACY1

Name	aminoacylase 1
Structure
Interactors	11 interactors: APP BCAS2 NPM1 NTAQ1 POT1 PRR35 TENT5B TERF1 TLX3 TTC1 WWOX
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Aminoacylase Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Amino Acid Metabolic Process
Pathways	Aflatoxin activation and detoxification Defective ACY1 causes encephalopathy Paracetamol ADME
Drugs	Aspartic acid Acetylcysteine Copper
GWAS	Serum metabolite concentrations in chronic kidney disease ( 33838163 )
Entrez ID	95
HPRD ID	00092
Ensembl ID	ENSG00000243989
Uniprot IDs	Q03154 V9HWA0
PDB IDs	1Q7L
GO Terms Enriched among Interactors ?	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Protein-N-terminal Glutamine Amidohydrolase Activity Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Negative Regulation Of Cell Cycle Regulation Of Endoribonuclease Activity Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Positive Regulation Of Telomeric Loop Disassembly Protein-N-terminal Asparagine Amidohydrolase Activity Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process