GFUS and RIOK2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GFUS	RIOK2
Description		GDP-L-fucose synthase	RIO kinase 2
Image
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Preribosome, Small Subunit Precursor
	Molecular Function	Catalytic Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Isomerase Activity GDP-4-dehydro-D-rhamnose Reductase Activity Identical Protein Binding GDP-mannose 3,5-epimerase Activity GDP-L-fucose Synthase Activity	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	T Cell Mediated Cytotoxicity Leukocyte Cell-cell Adhesion Nucleotide-sugar Biosynthetic Process Positive Regulation Of Endothelial Cell Migration GDP-mannose Metabolic Process 'de Novo' GDP-L-fucose Biosynthetic Process Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin	Regulation Of Mitotic Metaphase/anaphase Transition Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis Protein Autophosphorylation Positive Regulation Of Ribosomal Small Subunit Export From Nucleus Positive Regulation Of RRNA Processing
Pathways		GDP-fucose biosynthesis	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		NADH	Fostamatinib
Diseases
GWAS			Chronic mountain sickness ( 31417607) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: ID2 NEDD4 RIOK2 UBC	7 interacting genes: APP CSNK2A1 GFUS PRDM16 RELA RPRD1A SMAD3
Entrez ID		7264	55781
HPRD ID		00654	10193
Ensembl ID		ENSG00000104522	ENSG00000058729
Uniprot IDs		A0A140VKC8 Q13630	Q9BVS4
PDB IDs		4B8W 4B8Z 4BKP 4BL5 4E5Y	5DHF 6FDM 6FDN 6FDO 6G18 6G51 6HK6 7VBT 7WU0 9F81
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Nucleocytoplasmic Transport Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Ribosomal Small Subunit Export From Nucleus Regulation Of Nucleocytoplasmic Transport Transmembrane Transporter Binding Channel Inhibitor Activity Positive Regulation Of Intracellular Transport Endodermal Digestive Tract Morphogenesis Thigmotaxis Phosphothreonine Residue Binding Negative Regulation Of Dopaminergic Neuron Differentiation Bundle Of His Development Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Phosphoserine Residue Binding Regulation Of Intracellular Transport Beta-2 Adrenergic Receptor Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of B Cell Differentiation Peyer's Patch Development Locomotor Rhythm Tube Morphogenesis Nucleoplasm Enucleate Erythrocyte Differentiation Regulation Of Dopaminergic Neuron Differentiation Regulation Of Mitotic Cell Cycle Phase Transition Mucosa-associated Lymphoid Tissue Development Response To Metal Ion Response To Light Stimulus Membranous Septum Morphogenesis Positive Regulation Of Astrocyte Differentiation Sodium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Potassium Channel Inhibitor Activity Positive Regulation Of RRNA Processing Preribosome, Small Subunit Precursor Ventricular Cardiac Muscle Tissue Development Negative Regulation Of Oligodendrocyte Differentiation Endocardial Cushion Development Protein Modification Process Negative Regulation Of Sodium Ion Transport Regulation Of RRNA Processing Response To Lithium Ion Positive Regulation Of Macrophage Differentiation Embryonic Digestive Tract Morphogenesis Mammary Gland Epithelial Cell Differentiation Cellular Response To Lithium Ion	Negative Regulation Of MiRNA Transcription Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Protein Catabolic Process Identical Protein Binding Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Negative Regulation Of Protein Catabolic Process DNA-binding Transcription Factor Binding Response To Angiotensin Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Nitric Oxide Metabolic Process Transcription Cis-regulatory Region Binding Cellular Response To Growth Factor Stimulus Regulation Of Amyloid Precursor Protein Catabolic Process Transcription Coactivator Binding Regulation Of Wnt Signaling Pathway Response To Growth Factor Positive Regulation Of MiRNA Transcription Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nitric Oxide Biosynthetic Process Enzyme Binding Regulation Of Response To Calcium Ion Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Catabolic Process Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Lung Blood Pressure Positive Regulation Of MiRNA Metabolic Process Nuclear Mineralocorticoid Receptor Binding GDP-L-fucose Synthase Activity GDP-4-dehydro-D-rhamnose Reductase Activity GDP-mannose 3,5-epimerase Activity Regulation Of Inflammatory Response Response To Interleukin-1 DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA Binding Response To CAMP Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?