TNXB and TGM7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TNXB	TGM7
Description		tenascin XB	transglutaminase 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Tenascin Complex
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Collagen Fibril Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Triglyceride Metabolic Process Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Actin Cytoskeleton Organization Regulation Of Cell Adhesion Extracellular Matrix Organization Collagen Fibril Organization Regulation Of Cell Migration Neuron Projection Development Collagen Metabolic Process Regulation Of Cell Differentiation Regulation Of JNK Cascade Elastic Fiber Assembly Cell-cell Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Collagen Fibril Organization Positive Regulation Of Cell Fate Determination
Pathways		ECM proteoglycans
Drugs
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		A body shape index ( 34021172) Age-related macular degeneration ( 22694956) Alzheimer's disease ( 30636644) Asthma ( 31619474) Atopic dermatitis ( 23886662) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Coronary artery disease ( 32469254) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil count ( 27863252) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 30054594 29617998) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet distribution width ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Shingles ( 28928442) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26316170 26502338 28714469 21408207) Systolic blood pressure ( 28739976) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)
Interacting Genes		6 interacting genes: BANP CEACAM6 POU6F2 TGM7 VEGFA VEGFB	20 interacting genes: ARID5A CDSN FRS3 GEM HNRNPF HOXA1 KCTD1 KRT39 LAMTOR3 LNX1 PRKAB2 QARS1 SAXO4 SDS SPATA18 SPRY1 TNXB TSSK3 UNKL YPEL3
Entrez ID		7148	116179
HPRD ID		02993	09485
Ensembl ID		ENSG00000168477	ENSG00000159495
Uniprot IDs		A0A3B3ISX9 O95680 O95681 P22105 Q6IPK3 Q9Y464	Q96PF1
PDB IDs		2CUH 2CUI 2CUM
Enriched GO Terms of Interacting Partners?		Vascular Endothelial Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor 1 Binding Positive Regulation Of Mast Cell Chemotaxis Regulation Of Mast Cell Chemotaxis Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Vascular Wound Healing Receptor Ligand Activity Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Migration Regulation Of Establishment Of Endothelial Barrier Vascular Endothelial Growth Factor Signaling Pathway Induction Of Positive Chemotaxis Positive Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Positive Chemotaxis Negative Regulation Of MiRNA Transcription Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Leukocyte Migration Chemoattractant Activity Positive Regulation Of Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Sprouting Angiogenesis Positive Regulation Of Phosphorylation Regulation Of Endothelial Cell Differentiation Vascular Process In Circulatory System Positive Regulation Of DNA Biosynthetic Process Positive Chemotaxis Regulation Of ERK1 And ERK2 Cascade Regulation Of Vascular Permeability Identical Protein Binding Negative Regulation Of Apoptotic Process Vasodilation Positive Regulation Of Phosphate Metabolic Process Regulation Of Morphogenesis Of A Branching Structure Response To Decreased Oxygen Levels Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Hypoxia Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Fat Cell Differentiation Regulation Of Angiogenesis Circulatory System Process Negative Regulation Of Programmed Cell Death Regulation Of Vasculature Development Positive Regulation Of Cell Population Proliferation Response To Oxygen Levels Positive Regulation Of Cell-matrix Adhesion
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