TGM7 and SPRY1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGM7	SPRY1
Description		transglutaminase 7	sprouty RTK signaling antagonist 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Metal Ion Binding	Protein Binding
	Biological Process		Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Lens Fiber Cell Differentiation
Pathways			EGFR downregulation
Drugs
Diseases
GWAS			A body shape index ( 34021172) Apolipoprotein B levels ( 32203549) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Triglyceride levels ( 32203549)
Interacting Genes		20 interacting genes: ARID5A CDSN FRS3 GEM HNRNPF HOXA1 KCTD1 KRT39 LAMTOR3 LNX1 PRKAB2 QARS1 SAXO4 SDS SPATA18 SPRY1 TNXB TSSK3 UNKL YPEL3	87 interacting genes: ADAM12 ADAMTSL4 ANKRD11 ATXN7 CACNA1A CCDC57 CDR2L CHRD CREB5 CYSRT1 FARS2 FBLN1 FHL5 FXR1 FXR2 GEMIN4 GNE GRB2 GUCD1 HEXIM2 HOXA1 HRG HSF2BP INCA1 KPNA2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A MB21D2 MDFI MEOX2 NBPF19 NOTCH2NLA NTM OTX1 PCSK5 POLR1C PRKAA2 PRKAB2 R3HDM2 REL SMCP SOCS4 SPRY2 STAT3 TFAP2D TGM7 UBASH3A VWC2 YY1 ZNF23 ZNF330 ZNF417 ZNF441 ZNF837
Entrez ID		116179	10252
HPRD ID		09485	06782
Ensembl ID		ENSG00000159495	ENSG00000164056
Uniprot IDs		Q96PF1	O43609
PDB IDs
Enriched GO Terms of Interacting Partners?			Epidermis Development Keratin Filament Intermediate Filament Keratinization Tissue Development Identical Protein Binding Protein Binding Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?