TNXB

Name	tenascin XB
Structure
Novel Interactors	1 novel interactors: TNF
Interactors	6 interactors: BANP CEACAM6 POU6F2 TGM7 VEGFA VEGFB
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Tenascin Complex
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Collagen Fibril Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Triglyceride Metabolic Process Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Actin Cytoskeleton Organization Regulation Of Cell Adhesion Extracellular Matrix Organization Collagen Fibril Organization Regulation Of Cell Migration Neuron Projection Development Collagen Metabolic Process Regulation Of Cell Differentiation Regulation Of JNK Cascade Elastic Fiber Assembly Cell-cell Adhesion Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Collagen Fibril Organization Positive Regulation Of Cell Fate Determination
Pathways	ECM proteoglycans
Diseases	Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS	A body shape index ( 34021172 ) Age-related macular degeneration ( 22694956 ) Alzheimer's disease ( 30636644 ) Asthma ( 31619474 ) Atopic dermatitis ( 23886662 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Automobile speeding propensity ( 30643258 ) Coronary artery disease ( 32469254 ) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Eosinophil count ( 27863252 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hemoglobin levels ( 32327693 ) Hip circumference adjusted for BMI ( 34021172 ) HIV-1 control ( 20041166 ) Inflammatory bowel disease ( 28067908 ) Intraocular pressure ( 30054594 29617998 ) Lung cancer ( 28604730 ) Lung cancer in ever smokers ( 28604730 ) Mean corpuscular volume ( 27863252 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Neutrophil count ( 32888494 ) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377 ) Platelet distribution width ( 32888494 ) Prostate cancer ( 23535732 ) Refractive error ( 32231278 ) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848 ) Schizophrenia ( 30285260 ) Shingles ( 28928442 ) Squamous cell lung carcinoma ( 28604730 ) Sum eosinophil basophil counts ( 27863252 ) Systemic lupus erythematosus ( 26316170 26502338 28714469 21408207 ) Systolic blood pressure ( 28739976 ) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858 ) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858 ) Type 1 diabetes and autoimmune thyroid diseases ( 25936594 ) Ulcerative colitis ( 28067908 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 ) White blood cell count ( 32888494 27863252 )
Entrez ID	7148
HPRD ID	02993
Ensembl ID	ENSG00000168477
Uniprot IDs	A0A3B3ISX9 O95680 O95681 P22105 Q6IPK3 Q9Y464
PDB IDs	2CUH 2CUI 2CUM
GO Terms Enriched among Interactors ?	Vascular Endothelial Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor 1 Binding Positive Regulation Of Mast Cell Chemotaxis Regulation Of Mast Cell Chemotaxis Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Vascular Wound Healing Receptor Ligand Activity Regulation Of Endothelial Cell Proliferation Positive Regulation Of Leukocyte Migration Regulation Of Establishment Of Endothelial Barrier Vascular Endothelial Growth Factor Signaling Pathway Induction Of Positive Chemotaxis Positive Regulation Of Vascular Permeability Positive Regulation Of Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Positive Chemotaxis Negative Regulation Of MiRNA Transcription Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Leukocyte Migration Chemoattractant Activity Positive Regulation Of Protein Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Sprouting Angiogenesis Positive Regulation Of Phosphorylation Regulation Of Endothelial Cell Differentiation Vascular Process In Circulatory System Positive Regulation Of DNA Biosynthetic Process Positive Chemotaxis Regulation Of ERK1 And ERK2 Cascade Regulation Of Vascular Permeability Identical Protein Binding Negative Regulation Of Apoptotic Process Vasodilation Positive Regulation Of Phosphate Metabolic Process Regulation Of Morphogenesis Of A Branching Structure Response To Decreased Oxygen Levels Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Hypoxia Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Fat Cell Differentiation Regulation Of Angiogenesis Circulatory System Process Negative Regulation Of Programmed Cell Death Regulation Of Vasculature Development Positive Regulation Of Cell Population Proliferation Response To Oxygen Levels Positive Regulation Of Cell-matrix Adhesion