ZNF534 and C1QC

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ZNF534	C1QC
Name		zinc finger protein 534	complement C1q C chain
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Space Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Blood Microparticle Postsynapse Extrinsic Component Of Presynaptic Membrane Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Symbiont Cell Surface
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Immune System Process Immune Response Complement Activation, Classical Pathway Negative Regulation Of Granulocyte Differentiation Innate Immune Response Negative Regulation Of Macrophage Differentiation Synapse Pruning
Pathways		Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		None	Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		None	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		No GWAS studies recorded	Blood protein levels ( 30072576 )
Novel Interactors		None recorded	1 novel interactors: RALA
Interacting Genes		3 interacting genes: AGAP1 C1QC WDR83OS	6 interacting genes: C1QA C1QB FKBP2 PTX3 UBQLN2 ZNF534
Entrez ID		147658	714
HPRD ID		15824	00395
Ensembl ID		ENSG00000198633	ENSG00000159189
Uniprot IDs		Q1T7F5 Q1T7F6 Q76KX8	A0A024RAA7 A0A8Q3SIZ0 P02747
PDB IDs		Not available	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U
GO Terms Enriched among Interactors		Complement Component C1q Complex Complement Component C1 Complex Negative Regulation Of Granulocyte Differentiation IgM Binding Extrinsic Component Of Postsynaptic Membrane Extrinsic Component Of Presynaptic Membrane Negative Regulation Of Macrophage Differentiation Synapse Pruning Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Postsynaptic Endosome Regulation Of Granulocyte Differentiation IgG Binding Regulation Of Modification Of Postsynaptic Structure Symbiont Cell Surface Regulation Of Modification Of Synaptic Structure Regulation Of Macrophage Differentiation Protein Insertion Into ER Membrane Protein Folding Chaperone Complex Complement Activation, Classical Pathway Complement Activation Negative Regulation Of Myeloid Leukocyte Differentiation Phosphatidylserine Binding Protein Folding Chaperone	Complement Component C1q Complex IgM Binding Complement Component C1 Complex Synapse Pruning IgG Binding Symbiont Cell Surface Complement Activation, Classical Pathway Complement Activation Regulation Of Endocytosis Phosphatidylserine Binding Immune Effector Process Collagen Trimer Regulation Of Receptor Internalization Extracellular Matrix Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding Edg-2 Lysophosphatidic Acid Receptor Binding Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Vesicle-mediated Transport Regulation Of Receptor-mediated Endocytosis Vertebrate Eye-specific Patterning Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Cell Surface Innate Immune Response Ovarian Cumulus Expansion Negative Regulation Of Clathrin-dependent Endocytosis Defense Response To Symbiont Defense Response To Other Organism Extrinsic Component Of Postsynaptic Membrane Complement Component C1q Complex Binding Membrane Raft Localization Postsynapse FK506 Binding Virion Binding Synapse Organization Humoral Immune Response Neuron Remodeling Response To Yeast Host-mediated Suppression Of Viral Proces Negative Regulation Of Receptor Internalization Astrocyte Activation Negative Regulation Of Glycoprotein Metabolic Process Opsonization Positive Regulation Of ERAD Pathway Regulation Of Clathrin-dependent Endocytosis Response To Other Organism